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Zfp266 zinc finger protein 266 [ Mus musculus (house mouse) ]

Gene ID: 77519, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp266provided by MGI
Official Full Name
zinc finger protein 266provided by MGI
Primary source
MGI:MGI:1924769
See related
Ensembl:ENSMUSG00000060510 AllianceGenome:MGI:1924769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5330440G10Rik; 5730601F06Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in central nervous system; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human ZNF266 (zinc finger protein 266); ZNF561 (zinc finger protein 561); and ZNF562 (zinc finger protein 562). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 3.9), CNS E14 (RPKM 2.8) and 22 other tissues See more
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Genomic context

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See Zfp266 in Genome Data Viewer
Location:
9 A3; 9 7.56 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20406364..20432715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20495068..20521419, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 26 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene zinc finger protein 426 Neighboring gene predicted gene, 23316 Neighboring gene predicted gene, 46142 Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene zinc finger protein 846

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors. Kaemena DF, et al. Nat Commun, 2023 Jan 30. PMID 36717582, Free PMC Article
  2. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
    Title: B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082485.1 → NP_001075954.1  zinc finger protein 561

    See identical proteins and their annotated locations for NP_001075954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC171206, BC089552, BM941296, CJ053742
    Consensus CDS
    CCDS52732.1
    UniProtKB/TrEMBL
    E9Q2S7
    Related
    ENSMUSP00000134217.2, ENSMUST00000174462.8
    Conserved Domains (4) summary
    smart00349
    Location:41 → 97
    KRAB; krueppel associated box
    COG5048
    Location:397 → 588
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:429 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001135019.1 → NP_001128491.1  zinc finger protein 561

    See identical proteins and their annotated locations for NP_001128491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC171206, BC048701, BM941296, CJ053742
    Consensus CDS
    CCDS52732.1
    UniProtKB/TrEMBL
    E9Q2S7
    Related
    ENSMUSP00000066012.8, ENSMUST00000068296.8
    Conserved Domains (4) summary
    smart00349
    Location:41 → 97
    KRAB; krueppel associated box
    COG5048
    Location:397 → 588
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:429 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20406364..20432715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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