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Dnhd1 dynein heavy chain domain 1 [ Mus musculus (house mouse) ]

Gene ID: 77505, updated on 11-Apr-2024

Summary

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Official Symbol
Dnhd1provided by MGI
Official Full Name
dynein heavy chain domain 1provided by MGI
Primary source
MGI:MGI:1924755
See related
Ensembl:ENSMUSG00000030882 AllianceGenome:MGI:1924755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8030491N06Rik
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement. Predicted to be part of inner dynein arm. Is expressed in cartilage; central nervous system; genitourinary system; stomach; and trachea. Orthologous to human DNHD1 (dynein heavy chain domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 13.6), limb E14.5 (RPKM 1.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Dnhd1 in Genome Data Viewer
Location:
7 E3; 7 55.93 cM
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105299983..105371007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105650776..105721800)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9700 Neighboring gene ADP-ribosylation factor interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene predicted gene, 22504 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112892770-112893071 Neighboring gene ribosomal RNA processing 8 Neighboring gene integrin linked kinase Neighboring gene TATA-box binding protein associated factor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice. Tan C, et al. Am J Hum Genet, 2022 Jan 6. PMID 34932939, Free PMC Article
  2. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
    Title: Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm flagellum assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein heavy chain domain-containing protein 1
Names
coiled-coil domain-containing protein 35
dynein heavy chain domain 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370803.1 → NP_001357732.1  dynein heavy chain domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC121823, AC125227
    UniProtKB/Swiss-Prot
    D3Z2X2, F6YTV1, Q9CX41
    UniProtKB/TrEMBL
    A0A8Z1SZM7
    Related
    ENSMUSP00000121261.3, ENSMUST00000145988.9
    Conserved Domains (8) summary
    pfam12777
    Location:3198 → 3468
    MT; Microtubule-binding stalk of dynein motor
    pfam03028
    Location:4103 → 4222
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:1021 → 1469
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1652 → 2005
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12781
    Location:3663 → 3801
    AAA_9; ATP-binding dynein motor region D5
    pfam17852
    Location:2187 → 2347
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam18199
    Location:4519 → 4744
    Dynein_C; Dynein heavy chain C-terminal domain
    cl38985
    Location:2366 → 2533
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105299983..105371007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z2X2.3 GenPept UniProtKB/Swiss-Prot:D3Z2X2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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