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Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [ Mus musculus (house mouse) ]

Gene ID: 77300, updated on 5-Mar-2024

Summary

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Official Symbol
Raph1provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1provided by MGI
Primary source
MGI:MGI:1924550
See related
Ensembl:ENSMUSG00000026014 AllianceGenome:MGI:1924550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lpd; 9430025M21Rik; C730009O10Rik
Summary
Acts upstream of or within axon extension. Located in cell leading edge. Is expressed in telencephalon. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 6.0), CNS E18 (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C2; 1 30.48 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60509997..60606233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60471180..60567074, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neurobeachin like 1 Neighboring gene STARR-seq mESC enhancer starr_01063 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_01064 Neighboring gene STARR-seq mESC enhancer starr_01065 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene abl interactor 2 Neighboring gene STARR-seq mESC enhancer starr_01070 Neighboring gene SEC61 translocon subunit gamma, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_01072 Neighboring gene STARR-seq mESC enhancer starr_01073 Neighboring gene predicted gene 11578 Neighboring gene predicted gene, 38388 Neighboring gene predicted gene, 51626

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice. Bodo C, et al. Sci Rep, 2017 Jul 14. PMID 28710397, Free PMC Article
  2. Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma. Miller CL, et al. PLoS One, 2016. PMID 27045955, Free PMC Article
  3. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Pinheiro EM, et al. Nat Cell Biol, 2011 Jul 24. PMID 21785421, Free PMC Article
  4. A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex. Yoshinaga S, et al. J Neurosci, 2012 Aug 22. PMID 22915108, Free PMC Article
  5. Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4(+) T Cells. Lagarrigue F, et al. J Immunol, 2022 Mar 15. PMID 35197328, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration.
    Title: GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration.
  2. Detailed behavioural analysis of the resulting Nestin-Cre-Lpd knockout mouse line revealed a specific behavioural phenotype characterised by hyperactivity and increased anxiety.
    Title: Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice.
  3. Lpd directly binds active Rac, which regulates a direct interaction between Lpd and the Scar/WAVE complex
    Title: Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.
  4. Role of lamellipodin (Lpd) in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate.
    Title: Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-associated and pleckstrin homology domains-containing protein 1
Names
lamellipodin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045513.3 → NP_001038978.3  ras-associated and pleckstrin homology domains-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AA199065, AC158969, BI134311, CB246004, DV652147
    Consensus CDS
    CCDS48275.2
    UniProtKB/TrEMBL
    F2Z3U3
    Related
    ENSMUSP00000121023.3, ENSMUST00000140485.8
    Conserved Domains (3) summary
    cd01259
    Location:393 → 515
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:398 → 506
    PH; PH domain
    cl00155
    Location:270 → 351
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    60509997..60606233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312876.3 → XP_017168365.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    F2Z4B7
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  2. XM_030243573.1 → XP_030099433.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    F2Z4B7
    Conserved Domains (2) summary
    cd01259
    Location:393 → 515
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:268 → 357
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  3. XM_006496324.2 → XP_006496387.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd01259
    Location:418 → 540
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:293 → 382
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  4. XM_006496323.2 → XP_006496386.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd01259
    Location:420 → 542
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:295 → 384
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  5. XM_006496326.2 → XP_006496389.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006496389.1

    UniProtKB/TrEMBL
    F2Z4B7, G5E867
    Related
    ENSMUSP00000027168.6, ENSMUST00000027168.12
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  6. XM_006496322.2 → XP_006496385.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  7. XM_030243566.1 → XP_030099426.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X4

  8. XM_030243571.1 → XP_030099431.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F2Z4B7
    Conserved Domains (2) summary
    cd01259
    Location:420 → 542
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:295 → 384
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

  9. XM_006496327.3 → XP_006496390.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    F2Z4B7
    Conserved Domains (2) summary
    cd01259
    Location:445 → 567
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16136
    Location:320 → 409
    RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

RNA

  1. XR_373268.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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