U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Mus musculus (house mouse) ]

Gene ID: 77097, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tanc2provided by MGI
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by MGI
Primary source
MGI:MGI:2444121
See related
Ensembl:ENSMUSG00000053580 AllianceGenome:MGI:2444121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3526402J09Rik; 5730590C14Rik
Summary
Acts upstream of or within in utero embryonic development. Predicted to be located in axon; cytosol; and dendritic spine. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 11.5), CNS E18 (RPKM 11.4) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 E1; 11 68.73 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105480458..105820130)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105589460..105929304)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30908 Neighboring gene predicted gene, 35828 Neighboring gene predicted gene, 39422 Neighboring gene STARR-positive B cell enhancer mm9_chr11:105453342-105453643 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30909 Neighboring gene STARR-seq mESC enhancer starr_30910 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 53650 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 9910 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk. Garrett L, et al. Dis Model Mech, 2022 Mar 1. PMID 34964047, Free PMC Article
  2. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Kim SG, et al. Nat Commun, 2021 May 11. PMID 33976205, Free PMC Article
  3. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
  4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  5. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
    Title: Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
  2. Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
    Title: Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
  3. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
    Title: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
  4. these results implicate TANC2 in embryonic development.
    Title: Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in dense core granule cytoskeletal transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein TANC2
Names
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181071.3 → NP_851416.2  protein TANC2

    See identical proteins and their annotated locations for NP_851416.2

    Status: VALIDATED

    Source sequence(s)
    AI413677, AK051973, AK173111, AL596246, BP766228
    Consensus CDS
    CCDS36357.1
    UniProtKB/Swiss-Prot
    A2A683, A2A690, Q3TRZ3, Q5EBP6, Q69ZQ7
    Related
    ENSMUSP00000097904.4, ENSMUST00000100330.10
    Conserved Domains (10) summary
    cd00204
    Location:1094 → 1219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1247 → 1272
    TPR; TPR repeat [structural motif]
    pfam03153
    Location:1408 → 1633
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam12796
    Location:1104 → 1196
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:341 → 383
    AAA_16; AAA ATPase domain
    pfam13414
    Location:1293 → 1356
    TPR_11; TPR repeat
    pfam13428
    Location:1326 → 1368
    TPR_14; Tetratricopeptide repeat
    pfam13637
    Location:888 → 937
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1100 → 1130
    ANK; ANK repeat [structural motif]
    cl14876
    Location:395 → 539
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105480458..105820130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534472.4 → XP_006534535.1  protein TANC2 isoform X1

    Conserved Domains (7) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1515 → 1745
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1324 → 1442
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1331 → 1356
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415 → 500
    AAA_16; AAA ATPase domain

  2. XM_006534473.4 → XP_006534536.1  protein TANC2 isoform X2

    Conserved Domains (7) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1514 → 1744
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1324 → 1441
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1331 → 1356
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415 → 500
    AAA_16; AAA ATPase domain

  3. XM_006534482.5 → XP_006534545.1  protein TANC2 isoform X9

    Conserved Domains (4) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415 → 500
    AAA_16; AAA ATPase domain

  4. XM_006534474.4 → XP_006534537.1  protein TANC2 isoform X3

    Conserved Domains (7) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1505 → 1735
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1314 → 1432
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1321 → 1346
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415 → 500
    AAA_16; AAA ATPase domain

  5. XM_006534475.4 → XP_006534538.1  protein TANC2 isoform X4

    Conserved Domains (7) summary
    PHA03095
    Location:930 → 1224
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1504 → 1734
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1314 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1170 → 1296
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1321 → 1346
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:415 → 500
    AAA_16; AAA ATPase domain

  6. XM_006534483.5 → XP_006534546.1  protein TANC2 isoform X10

    Conserved Domains (5) summary
    PHA03095
    Location:1083 → 1303
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:878 → 1046
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:1174 → 1204
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1178 → 1270
    Ank_2; Ankyrin repeats (3 copies)
    pfam13191
    Location:415 → 500
    AAA_16; AAA ATPase domain

  7. XM_006534476.4 → XP_006534539.1  protein TANC2 isoform X5

    Conserved Domains (7) summary
    PHA03095
    Location:893 → 1187
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1478 → 1708
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:1287 → 1405
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1133 → 1259
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1294 → 1319
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1137 → 1167
    ANK; ANK repeat [structural motif]
    pfam13191
    Location:378 → 463
    AAA_16; AAA ATPase domain

  8. XM_006534477.4 → XP_006534540.1  protein TANC2 isoform X6

    Conserved Domains (7) summary
    PHA03095
    Location:893 → 1187
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1287 → 1405
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1133 → 1259
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1294 → 1319
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1137 → 1167
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:1493 → 1645
    Pro-rich; Proline-rich
    pfam13191
    Location:378 → 463
    AAA_16; AAA ATPase domain

  9. XM_006534478.3 → XP_006534541.1  protein TANC2 isoform X7

    Conserved Domains (7) summary
    PHA03095
    Location:856 → 1150
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1250 → 1368
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1096 → 1222
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1257 → 1282
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1100 → 1130
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:1456 → 1608
    Pro-rich; Proline-rich
    pfam13191
    Location:341 → 426
    AAA_16; AAA ATPase domain

  10. XM_006534480.5 → XP_006534543.1  protein TANC2 isoform X8

    See identical proteins and their annotated locations for XP_006534543.1

    Conserved Domains (7) summary
    PHA03095
    Location:766 → 1060
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1160 → 1278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1006 → 1132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1167 → 1192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1010 → 1040
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:1366 → 1518
    Pro-rich; Proline-rich
    pfam13191
    Location:251 → 336
    AAA_16; AAA ATPase domain

  11. XM_006534481.5 → XP_006534544.1  protein TANC2 isoform X8

    See identical proteins and their annotated locations for XP_006534544.1

    Conserved Domains (7) summary
    PHA03095
    Location:766 → 1060
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1160 → 1278
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG0666
    Location:1006 → 1132
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00006
    Location:1167 → 1192
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1010 → 1040
    ANK; ANK repeat [structural motif]
    pfam15240
    Location:1366 → 1518
    Pro-rich; Proline-rich
    pfam13191
    Location:251 → 336
    AAA_16; AAA ATPase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175492.2: Suppressed sequence

    Description
    NM_175492.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A690.1 GenPept UniProtKB/Swiss-Prot:A2A690

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous