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Tmco4 transmembrane and coiled-coil domains 4 [ Mus musculus (house mouse) ]

Gene ID: 77056, updated on 5-Mar-2024

Summary

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Official Symbol
Tmco4provided by MGI
Official Full Name
transmembrane and coiled-coil domains 4provided by MGI
Primary source
MGI:MGI:1924306
See related
Ensembl:ENSMUSG00000041143 AllianceGenome:MGI:1924306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632413C14Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMCO4 (transmembrane and coiled-coil domains 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 8.7), duodenum adult (RPKM 7.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Tmco4 in Genome Data Viewer
Location:
4 D3; 4 70.57 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138699588..138786484)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138972276..139059173)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52684 Neighboring gene predicted gene, 42333 Neighboring gene ring finger protein 186 Neighboring gene predicted gene, 33214 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4693 Neighboring gene NBL1, DAN family BMP antagonist

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domain-containing protein 4
Names
novel DUF726 domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305423.1 → NP_001292352.1  transmembrane and coiled-coil domain-containing protein 4

    See identical proteins and their annotated locations for NP_001292352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK014571, AK148086, AL805923, BB030219
    Consensus CDS
    CCDS18837.1
    UniProtKB/Swiss-Prot
    Q8BIX8, Q91WU4, Q9D675
    Related
    ENSMUSP00000041388.4, ENSMUST00000043042.10
    Conserved Domains (1) summary
    pfam05277
    Location:218 → 518
    DUF726; Protein of unknown function (DUF726)

  2. NM_029857.3 → NP_084133.1  transmembrane and coiled-coil domain-containing protein 4

    See identical proteins and their annotated locations for NP_084133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate exons in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029092, BB157255
    Consensus CDS
    CCDS18837.1
    UniProtKB/Swiss-Prot
    Q8BIX8, Q91WU4, Q9D675
    Related
    ENSMUSP00000059320.3, ENSMUST00000050949.9
    Conserved Domains (1) summary
    pfam05277
    Location:218 → 518
    DUF726; Protein of unknown function (DUF726)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138699588..138786484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539280.5 → XP_006539343.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006539343.1

    UniProtKB/Swiss-Prot
    Q8BIX8, Q91WU4, Q9D675
    Conserved Domains (1) summary
    pfam05277
    Location:218 → 518
    DUF726; Protein of unknown function (DUF726)

  2. XM_017320451.3 → XP_017175940.1  transmembrane and coiled-coil domain-containing protein 4 isoform X3

    Conserved Domains (1) summary
    cl21494
    Location:218 → 421
    Abhydrolase; alpha/beta hydrolases

  3. XM_036164544.1 → XP_036020437.1  transmembrane and coiled-coil domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    pfam05277
    Location:166 → 466
    DUF726; Protein of unknown function (DUF726)

RNA

  1. XR_001784218.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WU4.2 GenPept UniProtKB/Swiss-Prot:Q91WU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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