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Arid2 AT-rich interaction domain 2 [ Mus musculus (house mouse) ]

Gene ID: 77044, updated on 26-Mar-2024

Summary

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Official Symbol
Arid2provided by MGI
Official Full Name
AT-rich interaction domain 2provided by MGI
Primary source
MGI:MGI:1924294
See related
Ensembl:ENSMUSG00000033237 AllianceGenome:MGI:1924294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAF200; zipzap/p200; 1700124K17Rik; 4432409D24Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of transcription regulator complex. Is expressed in early conceptus and genitourinary system. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 22.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 52.37 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96185403..96303344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96287522..96405463)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38469 Neighboring gene RIKEN cDNA 4833422M21 gene Neighboring gene RIKEN cDNA E330033B04 gene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:96114695-96114804 Neighboring gene STARR-seq mESC enhancer starr_39586 Neighboring gene STARR-seq mESC enhancer starr_39587 Neighboring gene SR-related CTD-associated factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E9160 Neighboring gene STARR-positive B cell enhancer ABC_E8609 Neighboring gene predicted gene, 41408 Neighboring gene STARR-seq mESC enhancer starr_39591 Neighboring gene predicted gene, 41392

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2. Cao HJ, et al. Cell Death Differ, 2023 Feb. PMID 36396719, Free PMC Article
  2. Downregulation of AT-rich interaction domain 2 underlies natural killer cell dysfunction in oral squamous cell carcinoma. Li W, et al. Immunol Cell Biol, 2023 Jan. PMID 36269235
  3. PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse. de Castro RO, et al. Development, 2022 Sep 15. PMID 36111709, Free PMC Article
  4. Mammalian SWI/SNF chromatin remodeler is essential for reductional meiosis in males. Menon DU, et al. Nat Commun, 2021 Nov 12. PMID 34772938, Free PMC Article
  5. The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis. Liu L, et al. J Hematol Oncol, 2018 Feb 26. PMID 29482581, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
    Title: ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
  2. Downregulation of AT-rich interaction domain 2 underlies natural killer cell dysfunction in oral squamous cell carcinoma.
    Title: Downregulation of AT-rich interaction domain 2 underlies natural killer cell dysfunction in oral squamous cell carcinoma.
  3. ARID2 Deficiency Correlates with the Response to Immune Checkpoint Blockade in Melanoma.
    Title: ARID2 Deficiency Correlates with the Response to Immune Checkpoint Blockade in Melanoma.
  4. ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer.
    Title: ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer.
  5. Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis.
    Title: Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis.
  6. ARID2 knockout promotes pulmonary metastasis in different HCC mouse models.
    Title: Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.
  7. Increased Arid2-IR likely contributes to ECM production in DKD and that Egr1 promotes ECM production in DKD.
    Title: Early growth response protein-1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease.
  8. Baf200 deficiency accelerates the progression of MLL-AF9-induced leukemia.
    Title: The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis.
  9. a critical role for ARID2-containing complexes in promoting osteoblast differentiation and supports a view that the PBAF subset of SWI/SNF contributes importantly to maintaining cellular identity and activating tissue-specific gene expression.
    Title: Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression.
  10. zipzap may serve as a transcription co-activator for the regulation of cardiac gene expression
    Title: Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostatic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
part_of SWI/SNF superfamily-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF superfamily-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
AT-rich interactive domain-containing protein 2
Names
ARID domain-containing protein 2
AT rich interactive domain 2 (ARID, RFX-like)
AT rich interactive domain 2 (Arid-rfx like)
BRG1-associated factor 200
zinc finger protein with activation potential
zipzap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175251.4 → NP_780460.3  AT-rich interactive domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC133578, AK007269, AK077366, BU056807, CA749551, CK781204, CV559640
    Consensus CDS
    CCDS37185.2
    UniProtKB/Swiss-Prot
    E9Q7E2
    Related
    ENSMUSP00000093969.5, ENSMUST00000096250.5
    Conserved Domains (4) summary
    pfam01388
    Location:19 → 101
    ARID; ARID/BRIGHT DNA binding domain
    pfam02257
    Location:521 → 601
    RFX_DNA_binding; RFX DNA-binding domain
    cl26464
    Location:603 → 910
    Atrophin-1; Atrophin-1 family
    cl26809
    Location:1278 → 1575
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    96185403..96303344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159626.1 → XP_036015519.1  AT-rich interactive domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    PTZ00395
    Location:1129 → 1426
    PTZ00395; Sec24-related protein; Provisional
    pfam02257
    Location:372 → 452
    RFX_DNA_binding; RFX DNA-binding domain
    cl41773
    Location:527 → 1003
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q7E2.1 GenPept UniProtKB/Swiss-Prot:E9Q7E2

Gene LinkOut

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