Hyal4 hyaluronoglucosaminidase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hyal4provided by MGI
Official Full Name: hyaluronoglucosaminidase 4provided by MGI
Primary source: MGI:MGI:1924292
See related: Ensembl:ENSMUSG00000029680 AllianceGenome:MGI:1924292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CSHY; 4632428M18Rik
Summary: Enables hyalurononglucosaminidase activity. Acts upstream of or within chondroitin sulfate catabolic process. Located in cell surface. Is expressed in embryo and testis. Orthologous to human HYAL4 (hyaluronidase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 11.28 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (24748366..24766518)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (24748367..24766519)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).
Title: Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Markers

Hyal4 (e-PCR), detects polymorphism
- UniSTS:546826

NoName (e-PCR)
- UniSTS:548193

NoName (e-PCR)
- UniSTS:548194

NoName (e-PCR)
- UniSTS:548195

NoName (e-PCR)
- UniSTS:548196

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chondroitin hydrolase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hyalurononglucosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyalurononglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondroitin sulfate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chondroitin sulfate catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in hyaluronan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hyaluronidase-4

Names: chondroitin sulfate endo-beta-N-acetylgalactosaminidase; chondroitin sulfate hydrolase; hyal-4

NP_084124.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.