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Chst1 carbohydrate sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 76969, updated on 21-Apr-2024

Summary

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Official Symbol
Chst1provided by MGI
Official Full Name
carbohydrate sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1924219
See related
Ensembl:ENSMUSG00000027221 AllianceGenome:MGI:1924219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C6ST; Gst1; KSST; GST-1; KS6ST; KSGAL6ST; 2610008E20Rik
Summary
Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and keratan sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; galactose metabolic process; and keratan sulfate metabolic process. Predicted to act upstream of or within inflammatory response. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Is expressed in eye; limb; and nervous system. Orthologous to human CHST1 (carbohydrate sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 51.0), cortex adult (RPKM 49.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 51.17 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92429978..92445597)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92599632..92615252)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 7221 Neighboring gene microRNA 7222 Neighboring gene STARR-seq mESC enhancer starr_05147 Neighboring gene STARR-seq mESC enhancer starr_05149 Neighboring gene STARR-seq mESC enhancer starr_05150 Neighboring gene predicted gene 13816 Neighboring gene predicted gene, 39880 Neighboring gene predicted gene, 32413

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency. Kumagai T, et al. Glycobiology, 2018 Jun 1. PMID 29659839, Free PMC Article
  2. Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis. Foyez T, et al. Am J Pathol, 2015 Nov. PMID 26362733
  3. KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain. Hoshino H, et al. J Histochem Cytochem, 2014 Feb. PMID 24152993, Free PMC Article
  4. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. Yang J, et al. BMC Immunol, 2006 Jun 13. PMID 16772045, Free PMC Article
  5. N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Kawashima H, et al. Nat Immunol, 2005 Nov. PMID 16227985

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHST1 does not contribute to the synthesis of glycan ligands for Siglec-F in the airways, although its absence results in exaggerated accumulation of airway macrophages and lymphocytes.
    Title: Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency.
  2. KSGal6ST is essential for C-6 sulfation of Gal within keratan sulfate in early postnatal brains.
    Title: KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain.
  3. neither KSGal6ST nor C6ST-1 is required for Siglec-F ligand synthesis in leukocytes or lung tissue
    Title: Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables keratan sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables keratan sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in keratan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in keratan sulfate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratan sulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 1
Names
N-acetylglucosamine-6-O-sulfotransferase 1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
keratan sulfate Gal-6 sulfotransferase
NP_001343481.1
NP_001343482.1
NP_076339.1
XP_030108062.1
XP_030108063.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356552.1 → NP_001343481.1  carbohydrate sulfotransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AL683814
    Consensus CDS
    CCDS16450.1
    UniProtKB/Swiss-Prot
    Q9D0K5, Q9EQC0
    UniProtKB/TrEMBL
    Q3UY35
    Conserved Domains (1) summary
    pfam00685
    Location:198 → 384
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001356553.1 → NP_001343482.1  carbohydrate sulfotransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL683814
    Consensus CDS
    CCDS16450.1
    UniProtKB/Swiss-Prot
    Q9D0K5, Q9EQC0
    UniProtKB/TrEMBL
    Q3UY35
    Conserved Domains (1) summary
    pfam00685
    Location:198 → 384
    Sulfotransfer_1; Sulfotransferase domain

  3. NM_023850.2 → NP_076339.1  carbohydrate sulfotransferase 1

    See identical proteins and their annotated locations for NP_076339.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK011344, AK134997, CX238855
    Consensus CDS
    CCDS16450.1
    UniProtKB/Swiss-Prot
    Q9D0K5, Q9EQC0
    UniProtKB/TrEMBL
    Q3UY35
    Related
    ENSMUSP00000064246.7, ENSMUST00000065797.7
    Conserved Domains (1) summary
    pfam00685
    Location:198 → 384
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    92429978..92445597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252202.2 → XP_030108062.1  carbohydrate sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9D0K5, Q9EQC0
    UniProtKB/TrEMBL
    Q3UY35
    Conserved Domains (1) summary
    pfam00685
    Location:198 → 384
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_030252203.2 → XP_030108063.1  carbohydrate sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9D0K5, Q9EQC0
    UniProtKB/TrEMBL
    Q3UY35
    Conserved Domains (1) summary
    pfam00685
    Location:198 → 384
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQC0.1 GenPept UniProtKB/Swiss-Prot:Q9EQC0

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