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ZNF136 zinc finger protein 136 [ Homo sapiens (human) ]

Gene ID: 7695, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF136provided by HGNC
Official Full Name
zinc finger protein 136provided by HGNC
Primary source
HGNC:HGNC:12920
See related
Ensembl:ENSG00000196646 MIM:604078; AllianceGenome:HGNC:12920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pHZ-20
Summary
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.2), ovary (RPKM 4.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12163096..12189871)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12287953..12318112)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12273911..12300686)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF625-ZNF20 readthrough (NMD candidate) Neighboring gene ribosomal protein L17 pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12267212-12267903 Neighboring gene zinc finger protein 625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14046 Neighboring gene uncharacterized LOC100289333 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12315316-12315484 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12342780-12343609 Neighboring gene zinc finger protein 44 Neighboring gene ribosomal protein L28 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A potential cellular host factor homologous to ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis C virus. Liu C, et al. Arch Virol, 2014 Apr. PMID 24136724
  2. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing H, et al. FEBS Lett, 1995 Aug 7. PMID 7649249
  3. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
  4. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  5. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter T, et al. Mol Syst Biol, 2009. PMID 19156129, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Through peptide mass fingerprinting, the hepatitis C virus NS2-interacting protein was found to be homologous to a repressor of transcription, ZNF136.
    Title: A potential cellular host factor homologous to ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis C virus.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 136

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052983.1 RefSeqGene

    Range
    5050..31825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348013.2 → NP_001334942.1  zinc finger protein 136 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK299601, AL537987, BC006421, BP420506, BQ574220, CN429121, DB369850
    UniProtKB/Swiss-Prot
    P52737
    UniProtKB/TrEMBL
    B4DS70
    Conserved Domains (2) summary
    COG5048
    Location:91 → 460
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:188 → 208
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001348014.2 → NP_001334943.1  zinc finger protein 136 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, resulting in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL537987, BC006421, BP420506, BQ574220, CN429121, DA783495, DB369850
    Consensus CDS
    CCDS92526.1
    UniProtKB/TrEMBL
    A0A494C0J2
    Related
    ENSP00000498578.1, ENST00000652580.1
    Conserved Domains (2) summary
    COG5048
    Location:125 → 494
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_003437.5 → NP_003428.1  zinc finger protein 136 isoform 1

    See identical proteins and their annotated locations for NP_003428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer/longest* isoform (1).
    Source sequence(s)
    AL537987, BC006421, BP420506, BQ574220, CN429121, DB369850
    Consensus CDS
    CCDS32916.1
    UniProtKB/Swiss-Prot
    P52737
    Related
    ENSP00000344162.4, ENST00000343979.6
    Conserved Domains (3) summary
    COG5048
    Location:157 → 526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 44
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12163096..12189871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12287953..12318112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322009.1 → XP_054177984.1  zinc finger protein 136 isoform X1

    UniProtKB/Swiss-Prot
    P52737
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52737.1 GenPept UniProtKB/Swiss-Prot:P52737

Gene LinkOut

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