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Tsacc TSSK6 activating co-chaperone [ Mus musculus (house mouse) ]

Gene ID: 76927, updated on 5-Mar-2024

Summary

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Official Symbol
Tsaccprovided by MGI
Official Full Name
TSSK6 activating co-chaperoneprovided by MGI
Primary source
MGI:MGI:1924177
See related
Ensembl:ENSMUSG00000010538 AllianceGenome:MGI:1924177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIP; 1700021C14Rik
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein kinase inhibitor activity. Predicted to act upstream of or within positive regulation of protein kinase activity. Located in cytoplasm. Orthologous to human TSACC (TSSK6 activating cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 186.4) and genital fat pad adult (RPKM 3.2) See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 38.79 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88190059..88204306, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88282752..88296999, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3764 Neighboring gene microRNA 9b-1 Neighboring gene microRNA 9-1 Neighboring gene STARR-seq mESC enhancer starr_08177 Neighboring gene VISTA enhancer mm474 Neighboring gene Rhesus blood group-associated B glycoprotein Neighboring gene STARR-seq mESC enhancer starr_08178 Neighboring gene STARR-seq mESC enhancer starr_08179 Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene glycosylated lysosomal membrane protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. Jha KN, et al. J Biol Chem, 2010 Nov 5. PMID 20829357, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Homology

Clone Names

  • MGC130252

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TSSK6-activating co-chaperone protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357024.1 → NP_001343953.1  TSSK6-activating co-chaperone protein

    Status: VALIDATED

    Source sequence(s)
    AC044864, BF152860
    Consensus CDS
    CCDS17467.1
    UniProtKB/Swiss-Prot
    Q9DA44
    Related
    ENSMUSP00000103180.4, ENSMUST00000107556.10
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 124
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  2. NM_029801.3 → NP_084077.1  TSSK6-activating co-chaperone protein

    See identical proteins and their annotated locations for NP_084077.1

    Status: VALIDATED

    Source sequence(s)
    AC044864, AK006195
    Consensus CDS
    CCDS17467.1
    UniProtKB/Swiss-Prot
    Q9DA44
    Related
    ENSMUSP00000010682.4, ENSMUST00000010682.4
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 124
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88190059..88204306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252882.2 → XP_030108742.1  TSSK6-activating co-chaperone protein isoform X1

    Conserved Domains (1) summary
    pfam15836
    Location:1 → 149
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  2. XM_030252883.2 → XP_030108743.1  TSSK6-activating co-chaperone protein isoform X2

    Conserved Domains (1) summary
    pfam15836
    Location:29 → 146
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DA44.1 GenPept UniProtKB/Swiss-Prot:Q9DA44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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