U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mnd1 meiotic nuclear divisions 1 [ Mus musculus (house mouse) ]

Gene ID: 76915, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mnd1provided by MGI
Official Full Name
meiotic nuclear divisions 1provided by MGI
Primary source
MGI:MGI:1924165
See related
Ensembl:ENSMUSG00000033752 AllianceGenome:MGI:1924165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gaj; 2610034E18Rik
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in reciprocal meiotic recombination. Predicted to act upstream of or within DNA recombination and meiotic cell cycle. Predicted to be active in nucleus. Is expressed in branchial arch; central nervous system; embryo; forelimb bud; and somite. Orthologous to human MND1 (meiotic nuclear divisions 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 3.5), CNS E11.5 (RPKM 3.0) and 17 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 F1; 3 37.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83995240..84063084, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84087933..84155798, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4548 Neighboring gene predicted gene, 30352 Neighboring gene STARR-positive B cell enhancer ABC_E3440 Neighboring gene predicted gene, 30458 Neighboring gene STARR-positive B cell enhancer ABC_E7917 Neighboring gene STARR-positive B cell enhancer ABC_E9214 Neighboring gene STARR-positive B cell enhancer ABC_E1020 Neighboring gene STARR-seq mESC enhancer starr_08077 Neighboring gene tripartite motif-containing 2 Neighboring gene STARR-seq mESC enhancer starr_08078 Neighboring gene ribosomal protein L36a pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:84032505-84032806 Neighboring gene nuclear encoded tRNA glycine 9 (anticodon GCC) Neighboring gene predicted gene, 40078

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange. Pezza RJ, et al. Biophys J, 2010 Dec 1. PMID 21112301, Free PMC Article
  2. A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice. Tran TN, et al. Mol Hum Reprod, 2019 Oct 28. PMID 31393579, Free PMC Article
  3. The dual role of HOP2 in mammalian meiotic homologous recombination. Pezza RJ, et al. Nucleic Acids Res, 2014 Feb. PMID 24304900, Free PMC Article
  4. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Zhao W, et al. Nucleic Acids Res, 2014 Jan. PMID 24150939, Free PMC Article
  5. Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. Pezza RJ, et al. J Biol Chem, 2006 Jul 7. PMID 16675459

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assuming the mouse model accurately reflects the impact of this variant in humans, rs140107488 appears to be a benign allele that can be eliminated or de-prioritized in clinical genomic analyses of infertility patients.
    Title: A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice.
  2. HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
    Title: HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.
  3. The Hop2-Mnd1 heterodimer efficiently condenses double-stranded DNA via formation of a bright spot or DNA condensate.
    Title: Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange.
  4. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs
    Title: Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.
  5. Characterization of the MND1 gene in Saccharomyces cerevisiae and identification of a potential homolog in mouse.
    Title: The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.
  6. data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis [Mnd1]
    Title: The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
meiotic nuclear division protein 1 homolog
Names
meiotic nuclear divisions 1 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398662.1 → NP_001385591.1  meiotic nuclear division protein 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154875
    Conserved Domains (1) summary
    COG5124
    Location:5 → 179
    COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]

  2. NM_029797.4 → NP_084073.2  meiotic nuclear division protein 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_084073.2

    Status: VALIDATED

    Source sequence(s)
    AC154875
    Consensus CDS
    CCDS38464.1
    UniProtKB/Swiss-Prot
    Q8K396, Q9D0A1
    Related
    ENSMUSP00000048262.7, ENSMUST00000047368.8
    Conserved Domains (2) summary
    COG5124
    Location:5 → 204
    COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
    pfam03962
    Location:16 → 202
    Mnd1; Mnd1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    83995240..84063084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163403.1 → XP_036019296.1  meiotic nuclear division protein 1 homolog isoform X1

    Conserved Domains (1) summary
    COG5124
    Location:1 → 189
    COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K396.1 GenPept UniProtKB/Swiss-Prot:Q8K396

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous