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Ssbp4 single stranded DNA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 76900, updated on 5-Mar-2024

Summary

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Official Symbol
Ssbp4provided by MGI
Official Full Name
single stranded DNA binding protein 4provided by MGI
Primary source
MGI:MGI:1924150
See related
Ensembl:ENSMUSG00000070003 AllianceGenome:MGI:1924150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ssdp4; Sspb4; 1210002E11Rik
Summary
Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in gonad; limb; retina; telencephalon; and trunk somite. Orthologous to human SSBP4 (single stranded DNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 126.2), ovary adult (RPKM 102.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71050135..71061084, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70597485..70608387, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene elongation factor RNA polymerase II Neighboring gene STARR-positive B cell enhancer ABC_E1369 Neighboring gene myo-inositol 1-phosphate synthase A1 Neighboring gene STARR-positive B cell enhancer ABC_E3777 Neighboring gene STARR-positive B cell enhancer ABC_E3778 Neighboring gene STARR-positive B cell enhancer ABC_E3779 Neighboring gene leucine rich repeat containing 25 Neighboring gene STARR-positive B cell enhancer ABC_E6645 Neighboring gene STARR-seq mESC enhancer starr_21778 Neighboring gene growth differentiation factor 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Mozhui K, et al. Behav Genet, 2007 Jan. PMID 17131200
  2. Single-stranded DNA binding proteins are required for LIM complexes to induce transcriptionally active chromatin and specify spinal neuronal identities. Lee B, et al. Development, 2016 May 15. PMID 26965372, Free PMC Article
  3. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
  4. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
  5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
single-stranded DNA-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372468.1 → NP_001359397.1  single-stranded DNA-binding protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 366
    SSDP; Single-stranded DNA binding protein, SSDP

  2. NM_001372469.1 → NP_001359398.1  single-stranded DNA-binding protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 346
    SSDP; Single-stranded DNA binding protein, SSDP

  3. NM_001372470.1 → NP_001359399.1  single-stranded DNA-binding protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 366
    SSDP; Single-stranded DNA binding protein, SSDP

  4. NM_001372471.1 → NP_001359400.1  single-stranded DNA-binding protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 338
    SSDP; Single-stranded DNA binding protein, SSDP

  5. NM_001372472.1 → NP_001359401.1  single-stranded DNA-binding protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 338
    SSDP; Single-stranded DNA binding protein, SSDP

  6. NM_001372473.1 → NP_001359402.1  single-stranded DNA-binding protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 356
    SSDP; Single-stranded DNA binding protein, SSDP

  7. NM_001372475.1 → NP_001359404.1  single-stranded DNA-binding protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 318
    SSDP; Single-stranded DNA binding protein, SSDP

  8. NM_001372476.1 → NP_001359405.1  single-stranded DNA-binding protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC157774
    UniProtKB/TrEMBL
    A0A1B0GRX5
    Related
    ENSMUSP00000147704.2, ENSMUST00000210369.2
    Conserved Domains (1) summary
    pfam04503
    Location:1 → 237
    SSDP; Single-stranded DNA binding protein, SSDP

  9. NM_001372477.1 → NP_001359406.1  single-stranded DNA-binding protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Conserved Domains (1) summary
    pfam04503
    Location:1 → 237
    SSDP; Single-stranded DNA binding protein, SSDP

  10. NM_001372478.1 → NP_001359407.1  single-stranded DNA-binding protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Conserved Domains (1) summary
    pfam04503
    Location:1 → 237
    SSDP; Single-stranded DNA binding protein, SSDP

  11. NM_001372479.1 → NP_001359408.1  single-stranded DNA-binding protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Conserved Domains (1) summary
    pfam04503
    Location:1 → 237
    SSDP; Single-stranded DNA binding protein, SSDP

  12. NM_133772.3 → NP_598533.2  single-stranded DNA-binding protein 4 isoform 6

    See identical proteins and their annotated locations for NP_598533.2

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Consensus CDS
    CCDS22374.1
    UniProtKB/TrEMBL
    Q3U4B1, Q99LZ8
    Related
    ENSMUSP00000059039.10, ENSMUST00000049908.11
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 338
    SSDP; Single-stranded DNA binding protein, SSDP

RNA

  1. NR_164176.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Related
    ENSMUST00000211134.2

  2. NR_164177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157774

  3. NR_164178.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157774

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71050135..71061084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242338.4 → XP_011240640.1  single-stranded DNA-binding protein 4 isoform X6

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 346
    SSDP; Single-stranded DNA binding protein, SSDP

  2. XM_036154374.1 → XP_036010267.1  single-stranded DNA-binding protein 4 isoform X5

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 356
    SSDP; Single-stranded DNA binding protein, SSDP

  3. XM_011242337.4 → XP_011240639.1  single-stranded DNA-binding protein 4 isoform X4

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 384
    SSDP; Single-stranded DNA binding protein, SSDP

  4. XM_006509784.5 → XP_006509847.1  single-stranded DNA-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006509847.1

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 384
    SSDP; Single-stranded DNA binding protein, SSDP

  5. XM_036154375.1 → XP_036010268.1  single-stranded DNA-binding protein 4 isoform X7

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 318
    SSDP; Single-stranded DNA binding protein, SSDP

  6. XM_030243848.2 → XP_030099708.1  single-stranded DNA-binding protein 4 isoform X7

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 318
    SSDP; Single-stranded DNA binding protein, SSDP

  7. XM_011242336.4 → XP_011240638.1  single-stranded DNA-binding protein 4 isoform X3

    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 364
    SSDP; Single-stranded DNA binding protein, SSDP

  8. XM_006509790.5 → XP_006509853.1  single-stranded DNA-binding protein 4 isoform X5

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 356
    SSDP; Single-stranded DNA binding protein, SSDP

  9. XM_036154372.1 → XP_036010265.1  single-stranded DNA-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 384
    SSDP; Single-stranded DNA binding protein, SSDP

  10. XM_036154376.1 → XP_036010269.1  single-stranded DNA-binding protein 4 isoform X8

    Conserved Domains (1) summary
    pfam04503
    Location:45 → 290
    SSDP; Single-stranded DNA binding protein, SSDP

  11. XM_036154373.1 → XP_036010266.1  single-stranded DNA-binding protein 4 isoform X2

    UniProtKB/TrEMBL
    Q99LZ8
    Conserved Domains (2) summary
    smart00667
    Location:17 → 43
    LisH; Lissencephaly type-1-like homology motif
    pfam04503
    Location:81 → 366
    SSDP; Single-stranded DNA binding protein, SSDP
Nucleotide Protein Strain
Heading Accession and Version

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