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Golga1 golgin A1 [ Mus musculus (house mouse) ]

Gene ID: 76899, updated on 2-May-2024

Summary

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Official Symbol
Golga1provided by MGI
Official Full Name
golgin A1provided by MGI
Primary source
MGI:MGI:1924149
See related
Ensembl:ENSMUSG00000026754 AllianceGenome:MGI:1924149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
awag; Golgi97; golgin-97; 0710001G09Rik; 2210418B03Rik
Summary
Located in perinuclear region of cytoplasm and trans-Golgi network. Is expressed in embryo. Orthologous to human GOLGA1 (golgin A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 8.2), whole brain E14.5 (RPKM 7.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 24.42 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38906167..38955568, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39016155..39065551, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene suppressor of cancer cell invasion Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343 Neighboring gene developmental pluripotency associated 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis. Ramalho-Santos J, et al. Exp Cell Res, 2001 Jul 1. PMID 11412037
  2. Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula. Mikedis MM, et al. Gene Expr Patterns, 2013 Oct. PMID 23639725, Free PMC Article
  3. Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport. Pooley RD, et al. J Cell Sci, 2008 Oct 15. PMID 18827011, Free PMC Article
  4. A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Xie Z, et al. Dev Cell, 2018 Mar 26. PMID 29587143, Free PMC Article
  5. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91089

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
golgin subfamily A member 1
Names
golgi autoantigen, golgin subfamily a, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290649.1 → NP_001277578.1  golgin subfamily A member 1 isoform b

    See identical proteins and their annotated locations for NP_001277578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK163007, AL844588, BC053068
    Consensus CDS
    CCDS71049.1
    UniProtKB/TrEMBL
    Q66JW2
    Related
    ENSMUSP00000108471.3, ENSMUST00000112850.9
    Conserved Domains (2) summary
    smart00755
    Location:658 → 703
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    cl23717
    Location:230 → 293
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. NM_029793.2 → NP_084069.1  golgin subfamily A member 1 isoform a

    See identical proteins and their annotated locations for NP_084069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK163007, AL844588, BC043090, BY084848
    Consensus CDS
    CCDS16016.1
    UniProtKB/Swiss-Prot
    A3KGQ9, Q80YB0, Q9CW79
    UniProtKB/TrEMBL
    Q66JW2
    Related
    ENSMUSP00000037735.9, ENSMUST00000039165.15
    Conserved Domains (2) summary
    smart00755
    Location:683 → 728
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:151 → 504
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. NR_110968.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK028516, AK163007, AL844588, BY084848

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38906167..38955568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162691.1 → XP_036018584.1  golgin subfamily A member 1 isoform X1

    UniProtKB/TrEMBL
    Q66JW2
    Conserved Domains (3) summary
    smart00755
    Location:683 → 728
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:151 → 504
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    NF033930
    Location:441 → 671
    pneumo_PspA; pneumococcal surface protein A

  2. XM_030252197.2 → XP_030108057.1  golgin subfamily A member 1 isoform X2

    UniProtKB/Swiss-Prot
    A3KGQ9, Q80YB0, Q9CW79
    UniProtKB/TrEMBL
    Q66JW2
    Conserved Domains (2) summary
    smart00755
    Location:683 → 728
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:151 → 504
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_036162693.1 → XP_036018586.1  golgin subfamily A member 1 isoform X1

    UniProtKB/TrEMBL
    Q66JW2
    Conserved Domains (3) summary
    smart00755
    Location:683 → 728
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    TIGR02168
    Location:151 → 504
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    NF033930
    Location:441 → 671
    pneumo_PspA; pneumococcal surface protein A

RNA

  1. XR_866026.4 RNA Sequence

  2. XR_001783203.3 RNA Sequence

  3. XR_004940769.1 RNA Sequence

  4. XR_004940768.1 RNA Sequence

  5. XR_866025.4 RNA Sequence

  6. XR_004940767.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CW79.2 GenPept UniProtKB/Swiss-Prot:Q9CW79

Gene LinkOut

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