Bicd2 BICD cargo adaptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bicd2provided by MGI
Official Full Name: BICD cargo adaptor 2provided by MGI
Primary source: MGI:MGI:1924145
See related: Ensembl:ENSMUSG00000037933 AllianceGenome:MGI:1924145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables several functions, including dynactin binding activity; dynein complex binding activity; and dynein light intermediate chain binding activity. Involved in several processes, including microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Acts upstream of or within microtubule-based movement. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominance 2A and spinal muscular atrophy with lower extremity predominante 2B. Orthologous to human BICD2 (BICD cargo adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 19.5), testis adult (RPKM 16.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.22 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49495025..49540502)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49341549..49387026)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice.
Title: Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice.
Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy.
Title: Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy.
Findings demonstrate a novel, cell-intrinsic role of BICD2 in cortical neuron migration in vivo and provide new insights into BICD2-dependent dynein-mediated functions during cortical development.
Title: Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo.
Data suggest that binding of Lis1 to DDB complex does not strongly disrupt processive motility along microtubules; motile DDB complex binds up to two Lis1 dimers; mutational analysis suggested that Lis1 binds directly to the dynein motor domains during DDB complex movement. (Lis1 = lissencephaly 1 protein; DDB complex = dynein-dynactin-BicD2 complex; BicD2 = bicaudal D homolog 2 protein)
Title: Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.
several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells
Title: Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
Data indicate that Bicaudal-D2 (BICD2)-deficient mice develop disrupted laminar organization of cerebral cortex and the cerebellum, pointing to impaired radial neuronal migration.
Title: A role for Bicaudal-D2 in radial cerebellar granule cell migration.
LIS1 is required for dynein-mediated transport induced by membrane tethering of BICD2-N and LIS1 contributes to dynein accumulation at microtubule plus ends and BICD2-positive cellular structures.
Title: BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.
BICD2-N transgene increased lifespan in 'low copy' SOD1-G93A ALS transgenic mice.
Title: A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124775 (e-PCR)
- UniSTS:161597

G06234 (e-PCR)
- UniSTS:79236

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal anchor activity	IEA Inferred from Electronic Annotation more info
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynactin binding	IDA Inferred from Direct Assay more info	PubMed
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in microtubule anchoring at microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule anchoring at microtubule organizing center	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in minus-end-directed organelle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein bicaudal D homolog 2

Names: bic-D 2; bicaudal D homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039179.2 → NP_001034268.1 protein bicaudal D homolog 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK122348, BP775855, CF538535

Consensus CDS

CCDS36657.1

UniProtKB/TrEMBL

Q3TBD4

Related

ENSMUSP00000039394.7, ENSMUST00000048544.14

Conserved Domains (3) summary

pfam09730
Location:83 → 797

BicD; Microtubule-associated protein Bicaudal-D

cl19219
Location:55 → 169

DUF342; Protein of unknown function (DUF342)

cl19252
Location:178 → 230

MreC; rod shape-determining protein MreC
NM_001039180.2 → NP_001034269.1 protein bicaudal D homolog 2 isoform 3

See identical proteins and their annotated locations for NP_001034269.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in both UTRs and the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform is shorter, compared to isoform 1.

Source sequence(s)

AK122348, BP775855, CF538535

Consensus CDS

CCDS49261.1

UniProtKB/TrEMBL

D3Z390, Q3TBD4

Related

ENSMUSP00000105711.3, ENSMUST00000110084.4

Conserved Domains (2) summary

pfam09730
Location:9 → 723

BicD; Microtubule-associated protein Bicaudal-D

cl19252
Location:104 → 156

MreC; rod shape-determining protein MreC
NM_029791.4 → NP_084067.1 protein bicaudal D homolog 2 isoform 2

See identical proteins and their annotated locations for NP_084067.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding sequence and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK122348, BP775855, CF538535

Consensus CDS

CCDS36656.1

UniProtKB/Swiss-Prot

Q80TU1, Q8BTE3, Q921C5, Q9DCL3

UniProtKB/TrEMBL

Q3TBD4

Related

ENSMUSP00000105712.4, ENSMUST00000110085.11

Conserved Domains (3) summary

pfam09730
Location:83 → 797

BicD; Microtubule-associated protein Bicaudal-D

cl19219
Location:55 → 169

DUF342; Protein of unknown function (DUF342)

cl19252
Location:178 → 230

MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

49495025..49540502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244429.4 → XP_011242731.1 protein bicaudal D homolog 2 isoform X1

Conserved Domains (1) summary

pfam09730
Location:23 → 618

BicD; Microtubule-associated protein Bicaudal-D