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Coq8b coenzyme Q8B [ Mus musculus (house mouse) ]

Gene ID: 76889, updated on 5-Mar-2024

Summary

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Official Symbol
Coq8bprovided by MGI
Official Full Name
coenzyme Q8Bprovided by MGI
Primary source
MGI:MGI:1924139
See related
Ensembl:ENSMUSG00000003762 AllianceGenome:MGI:1924139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adck4; 0610012P18Rik
Summary
Predicted to enable kinase activity. Predicted to be involved in cerebellar Purkinje cell layer morphogenesis and ubiquinone biosynthetic process. Predicted to act upstream of or within phosphorylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9. Orthologous to human COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 18.8), ovary adult (RPKM 9.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 15.85 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26928112..26957374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27228676..27257949)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actin maturation protease Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C Neighboring gene STARR-positive B cell enhancer ABC_E2229 Neighboring gene STARR-positive B cell enhancer ABC_E4906 Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28101108-28101366 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28117793-28117976 Neighboring gene predicted gene, 30543

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. Widmeier E, et al. J Am Soc Nephrol, 2020 Jun. PMID 32381600, Free PMC Article
  2. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
  3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC101983, MGC102655

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cerebellar Purkinje cell layer morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
atypical kinase COQ8B, mitochondrial
Names
aarF domain containing kinase 4
aarF domain-containing protein kinase 4
coenzyme Q protein 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133770.2 → NP_598531.2  atypical kinase COQ8B, mitochondrial

    See identical proteins and their annotated locations for NP_598531.2

    Status: VALIDATED

    Source sequence(s)
    AK002619, AK079366, AK137168, BB770607, BY202506
    Consensus CDS
    CCDS39847.1
    UniProtKB/Swiss-Prot
    Q566J8, Q5XJH7, Q91WT5
    UniProtKB/TrEMBL
    E9QLB8
    Related
    ENSMUSP00000003860.7, ENSMUST00000003860.13
    Conserved Domains (1) summary
    cd13970
    Location:176 → 425
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26928112..26957374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540422.4 → XP_006540485.1  atypical kinase COQ8B, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006540485.1

    UniProtKB/Swiss-Prot
    Q566J8, Q5XJH7, Q91WT5
    UniProtKB/TrEMBL
    E9QLB8
    Conserved Domains (1) summary
    cd13970
    Location:176 → 425
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

  2. XM_036153553.1 → XP_036009446.1  atypical kinase COQ8B, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q566J8, Q5XJH7, Q91WT5
    UniProtKB/TrEMBL
    E9QLB8
    Conserved Domains (1) summary
    cd13970
    Location:176 → 425
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

  3. XM_011250741.4 → XP_011249043.1  atypical kinase COQ8B, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A0R4J1X1
    Related
    ENSMUSP00000123309.2, ENSMUST00000128090.8
    Conserved Domains (1) summary
    cl21453
    Location:176 → 299
    PKc_like; Protein Kinases, catalytic domain

  4. XM_017312382.3 → XP_017167871.1  atypical kinase COQ8B, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd13970
    Location:17 → 266
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

  5. XM_006540421.2 → XP_006540484.1  atypical kinase COQ8B, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006540484.1

    UniProtKB/Swiss-Prot
    Q566J8, Q5XJH7, Q91WT5
    UniProtKB/TrEMBL
    E9QLB8
    Related
    ENSMUSP00000104015.4, ENSMUST00000108378.10
    Conserved Domains (1) summary
    cd13970
    Location:176 → 425
    ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

RNA

  1. XR_391109.2 RNA Sequence

  2. XR_004934204.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q566J8.1 GenPept UniProtKB/Swiss-Prot:Q566J8

Gene LinkOut

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