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Rab36 RAB36, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 76877, updated on 11-Apr-2024

Summary

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Official Symbol
Rab36provided by MGI
Official Full Name
RAB36, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1924127
See related
Ensembl:ENSMUSG00000020175 AllianceGenome:MGI:1924127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330593L16Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to act upstream of or within protein transport. Predicted to be located in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human RAB36 (RAB36, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 8.5), ovary adult (RPKM 7.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 38.49 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (74872727..74890580)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75036895..75054748)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene radial spoke head homolog 14 (Chlamydomonas) Neighboring gene guanine nucleotide binding protein, alpha z subunit Neighboring gene predicted gene, 40692 Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene STARR-positive B cell enhancer ABC_E10622 Neighboring gene STARR-positive B cell enhancer mm9_chr10:74614065-74614365 Neighboring gene STARR-seq mESC enhancer starr_27150 Neighboring gene STARR-positive B cell enhancer ABC_E2943 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene STARR-seq mESC enhancer starr_27151 Neighboring gene predicted gene, 46234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes. Matsui T, et al. J Biol Chem, 2012 Aug 17. PMID 22740695, Free PMC Article
  2. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
  3. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
  4. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12578829
  5. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP.
    Title: The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-36
NP_001346199.1
NP_001346200.1
NP_001346201.1
XP_006514350.1
XP_006514352.1
XP_006514353.1
XP_006514355.1
XP_006514356.1
XP_006514357.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359270.1 → NP_001346199.1  ras-related protein Rab-36

    Status: VALIDATED

    Source sequence(s)
    AK038445, BQ173929, BY281467
    Consensus CDS
    CCDS23923.2
    UniProtKB/Swiss-Prot
    Q8CAM5
    UniProtKB/TrEMBL
    Q3V389
    Related
    ENSMUSP00000119399.2, ENSMUST00000147802.9
    Conserved Domains (1) summary
    cl38936
    Location:58 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001359271.1 → NP_001346200.1  ras-related protein Rab-36

    Status: VALIDATED

    Source sequence(s)
    AK046113, BQ173929, BY281467, CJ315423
    Consensus CDS
    CCDS23923.2
    UniProtKB/Swiss-Prot
    Q8CAM5
    UniProtKB/TrEMBL
    Q3V389
    Conserved Domains (1) summary
    cl38936
    Location:58 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001359272.1 → NP_001346201.1  ras-related protein Rab-36

    Status: VALIDATED

    Source sequence(s)
    AC142500, AK038445, AK142415, BQ173929, CJ315423
    Consensus CDS
    CCDS23923.2
    UniProtKB/Swiss-Prot
    Q8CAM5
    UniProtKB/TrEMBL
    Q3V389
    Related
    ENSMUSP00000121693.2, ENSMUST00000146440.3
    Conserved Domains (1) summary
    cl38936
    Location:58 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    74872727..74890580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514289.1 → XP_006514352.1  ras-related protein Rab-36 isoform X1

    See identical proteins and their annotated locations for XP_006514352.1

    UniProtKB/Swiss-Prot
    Q8CAM5
    UniProtKB/TrEMBL
    Q3V389
    Conserved Domains (1) summary
    cl38936
    Location:58 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006514287.1 → XP_006514350.1  ras-related protein Rab-36 isoform X1

    See identical proteins and their annotated locations for XP_006514350.1

    UniProtKB/Swiss-Prot
    Q8CAM5
    UniProtKB/TrEMBL
    Q3V389
    Conserved Domains (1) summary
    cl38936
    Location:58 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006514290.1 → XP_006514353.1  ras-related protein Rab-36 isoform X1

    See identical proteins and their annotated locations for XP_006514353.1

    UniProtKB/Swiss-Prot
    Q8CAM5
    UniProtKB/TrEMBL
    Q3V389
    Conserved Domains (1) summary
    cl38936
    Location:58 → 223
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_006514293.1 → XP_006514356.1  ras-related protein Rab-36 isoform X2

    See identical proteins and their annotated locations for XP_006514356.1

    Conserved Domains (1) summary
    cl38936
    Location:58 → 132
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_006514294.4 → XP_006514357.1  ras-related protein Rab-36 isoform X2

    See identical proteins and their annotated locations for XP_006514357.1

    Conserved Domains (1) summary
    cl38936
    Location:58 → 132
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_006514292.3 → XP_006514355.1  ras-related protein Rab-36 isoform X2

    See identical proteins and their annotated locations for XP_006514355.1

    Conserved Domains (1) summary
    cl38936
    Location:58 → 132
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_380455.1 RNA Sequence

  2. XR_004936302.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029781.3: Suppressed sequence

    Description
    NM_029781.3: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAM5.1 GenPept UniProtKB/Swiss-Prot:Q8CAM5

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