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Dcun1d5 defective in cullin neddylation 1 domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 76863, updated on 5-Mar-2024

Summary

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Official Symbol
Dcun1d5provided by MGI
Official Full Name
defective in cullin neddylation 1 domain containing 5provided by MGI
Primary source
MGI:MGI:1924113
See related
Ensembl:ENSMUSG00000032002 AllianceGenome:MGI:1924113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCNL5; 3110001A18Rik; 4833420K19Rik; D430047L21Rik
Summary
Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including positive regulation of protein modification by small protein conjugation or removal; protein neddylation; and regulation of cell growth. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; jaw; nervous system; and thymus primordium. Orthologous to human DCUN1D5 (defective in cullin neddylation 1 domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.2), adrenal adult (RPKM 24.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A1; 9 2.46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7176590..7220880)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7176590..7220880)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23196 Neighboring gene predicted gene, 23097 Neighboring gene STARR-seq mESC enhancer starr_23197 Neighboring gene STARR-seq mESC enhancer starr_23198 Neighboring gene STARR-seq mESC enhancer starr_23199 Neighboring gene STARR-seq mESC enhancer starr_23200 Neighboring gene predicted gene, 53497 Neighboring gene STARR-seq mESC enhancer starr_23204 Neighboring gene STARR-seq mESC enhancer starr_23205 Neighboring gene STARR-seq mESC enhancer starr_23206 Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E6712 Neighboring gene predicted gene, 31639 Neighboring gene matrix metallopeptidase 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. Thomas Y, et al. PLoS One, 2018. PMID 29958295, Free PMC Article
  2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling.
    Title: The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DCN1-like protein 5
Names
DCN1, defective in cullin neddylation 1, domain containing 5
DCUN1 domain-containing protein 5
defective in cullin neddylation protein 1-like protein 5
squamous cell carcinoma-related oncogene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357483.1 → NP_001344412.1  DCN1-like protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC174457, AK012764, AK134862, CO801841
    Consensus CDS
    CCDS90493.1
    UniProtKB/TrEMBL
    A0A1N9M8A6
    Related
    ENSMUSP00000034499.10, ENSMUST00000034499.10
    Conserved Domains (1) summary
    pfam03556
    Location:120 → 185
    Cullin_binding; Cullin binding

  2. NM_001357484.1 → NP_001344413.1  DCN1-like protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and contains an alternate exon in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC155908, AC174457
    Conserved Domains (1) summary
    pfam03556
    Location:51 → 161
    Cullin_binding; Cullin binding

  3. NM_029775.3 → NP_084051.1  DCN1-like protein 5 isoform 2

    See identical proteins and their annotated locations for NP_084051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC174457, AK134862, CO801841
    Consensus CDS
    CCDS40529.1
    UniProtKB/Swiss-Prot
    Q5XKI2, Q9CUS4, Q9CXV9
    Related
    ENSMUSP00000150564.2, ENSMUST00000215683.2
    Conserved Domains (1) summary
    pfam03556
    Location:120 → 230
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7176590..7220880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509889.5 → XP_006509952.1  DCN1-like protein 5 isoform X2

    Conserved Domains (1) summary
    pfam03556
    Location:120 → 219
    Cullin_binding; Cullin binding

  2. XM_030244711.1 → XP_030100571.1  DCN1-like protein 5 isoform X1

    Conserved Domains (1) summary
    pfam03556
    Location:199 → 309
    Cullin_binding; Cullin binding

RNA

  1. XR_004935592.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXV9.1 GenPept UniProtKB/Swiss-Prot:Q9CXV9

Gene LinkOut

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