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Spopl speckle-type BTB/POZ protein-like [ Mus musculus (house mouse) ]

Gene ID: 76857, updated on 11-Apr-2024

Summary

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Official Symbol
Spoplprovided by MGI
Official Full Name
speckle-type BTB/POZ protein-likeprovided by MGI
Primary source
MGI:MGI:1924107
See related
Ensembl:ENSMUSG00000026771 AllianceGenome:MGI:1924107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921517N04Rik; E430033K04Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.2), placenta adult (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 15.48 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23382942..23462139, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (23507466..23572132, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene POTE ankyrin domain family, member G like Neighboring gene predicted gene 13422 Neighboring gene neurexophilin 2 Neighboring gene STARR-seq mESC enhancer starr_03927 Neighboring gene predicted gene, 34769 Neighboring gene STARR-seq mESC enhancer starr_03928 Neighboring gene STARR-seq mESC enhancer starr_03929 Neighboring gene STARR-seq mESC enhancer starr_03930 Neighboring gene STARR-seq mESC enhancer starr_03931 Neighboring gene ubiquitin-conjugating enzyme E2D 3 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:23427670-23427971 Neighboring gene STARR-seq mESC enhancer starr_03932 Neighboring gene SH3 domain protein 2C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03933 Neighboring gene STARR-seq mESC enhancer starr_03934 Neighboring gene STARR-seq mESC enhancer starr_03935 Neighboring gene STARR-seq mESC enhancer starr_03936 Neighboring gene STARR-seq mESC enhancer starr_03937 Neighboring gene STARR-seq mESC enhancer starr_03939 Neighboring gene STARR-seq mESC enhancer starr_03940 Neighboring gene STARR-seq mESC enhancer starr_03942 Neighboring gene histamine N-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern. Choo KB, et al. Gene, 2010 Jul 15. PMID 20399258
  2. Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Cai H, et al. Dev Biol, 2017 Dec 1. PMID 28412462, Free PMC Article
  3. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Zhang Q, et al. Dev Cell, 2006 Jun. PMID 16740475
  4. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Cai H, et al. Proc Natl Acad Sci U S A, 2016 Dec 20. PMID 27930311, Free PMC Article
  5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130583

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
speckle-type POZ protein-like
Names
HIB homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165997.1 → NP_001159469.1  speckle-type POZ protein-like isoform b

    See identical proteins and their annotated locations for NP_001159469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AK014913, BC111867, CJ128267, CK329864
    UniProtKB/Swiss-Prot
    Q2M2N2
    Conserved Domains (2) summary
    cd18343
    Location:104 → 226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222 → 317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

  2. NM_001165998.1 → NP_001159470.1  speckle-type POZ protein-like isoform b

    See identical proteins and their annotated locations for NP_001159470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AK014913, BC111867, CJ128267, CK329864
    UniProtKB/Swiss-Prot
    Q2M2N2
    Conserved Domains (2) summary
    cd18343
    Location:104 → 226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222 → 317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

  3. NM_029773.2 → NP_084049.2  speckle-type POZ protein-like isoform a

    See identical proteins and their annotated locations for NP_084049.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK014913, BC111867, CJ128267, CK329864
    Consensus CDS
    CCDS15730.1
    UniProtKB/Swiss-Prot
    A2AL52, Q2M2N2, Q3TSH4
    Related
    ENSMUSP00000114974.2, ENSMUST00000132484.7
    Conserved Domains (3) summary
    cd18519
    Location:297 → 392
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:28 → 166
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:179 → 301
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    23382942..23462139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498412.5 → XP_006498475.1  speckle-type POZ protein-like isoform X1

    Conserved Domains (3) summary
    cd18519
    Location:309 → 404
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:80 → 178
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:191 → 313
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_030252196.2 → XP_030108056.1  speckle-type POZ protein-like isoform X5

    Conserved Domains (2) summary
    cd18343
    Location:104 → 226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222 → 317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

  3. XM_036162679.1 → XP_036018572.1  speckle-type POZ protein-like isoform X3

    Conserved Domains (3) summary
    cd18519
    Location:266 → 361
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:37 → 135
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:148 → 270
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  4. XM_036162681.1 → XP_036018574.1  speckle-type POZ protein-like isoform X5

    Conserved Domains (2) summary
    cd18343
    Location:104 → 226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222 → 317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

  5. XM_036162682.1 → XP_036018575.1  speckle-type POZ protein-like isoform X5

    Conserved Domains (2) summary
    cd18343
    Location:104 → 226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222 → 317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

  6. XM_036162683.1 → XP_036018576.1  speckle-type POZ protein-like isoform X5

    Conserved Domains (2) summary
    cd18343
    Location:104 → 226
    BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
    cd18519
    Location:222 → 317
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

  7. XM_036162680.1 → XP_036018573.1  speckle-type POZ protein-like isoform X4

    Conserved Domains (3) summary
    cd18519
    Location:263 → 358
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:1 → 132
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:145 → 267
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  8. XM_006498414.4 → XP_006498477.1  speckle-type POZ protein-like isoform X2

    See identical proteins and their annotated locations for XP_006498477.1

    UniProtKB/Swiss-Prot
    A2AL52, Q2M2N2, Q3TSH4
    Conserved Domains (3) summary
    cd18519
    Location:297 → 392
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:28 → 166
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:179 → 301
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  9. XM_030252195.2 → XP_030108055.1  speckle-type POZ protein-like isoform X2

    UniProtKB/Swiss-Prot
    A2AL52, Q2M2N2, Q3TSH4
    Conserved Domains (3) summary
    cd18519
    Location:297 → 392
    BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
    cl02446
    Location:28 → 166
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:179 → 301
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  10. XM_006498417.5 → XP_006498480.1  speckle-type POZ protein-like isoform X6

    Conserved Domains (2) summary
    cl02446
    Location:80 → 178
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:191 → 291
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  11. XM_036162684.1 → XP_036018577.1  speckle-type POZ protein-like isoform X7

    Conserved Domains (2) summary
    cl02446
    Location:80 → 178
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl38908
    Location:191 → 255
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RNA

  1. XR_866023.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2M2N2.3 GenPept UniProtKB/Swiss-Prot:Q2M2N2

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