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Kdm4c lysine (K)-specific demethylase 4C [ Mus musculus (house mouse) ]

Gene ID: 76804, updated on 11-Apr-2024

Summary

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Official Symbol
Kdm4cprovided by MGI
Official Full Name
lysine (K)-specific demethylase 4Cprovided by MGI
Primary source
MGI:MGI:1924054
See related
Ensembl:ENSMUSG00000028397 AllianceGenome:MGI:1924054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gasc1; Jmjd2c; 2410141F18Rik
Summary
Enables androgen receptor binding activity; enzyme binding activity; and histone demethylase activity. Acts upstream of or within several processes, including blastocyst formation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in early conceptus; eye; genitourinary system; hippocampus; and rib. Human ortholog(s) of this gene implicated in autistic disorder; breast cancer; carcinoma (multiple); head and neck cancer; and withdrawal disorder. Orthologous to human KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.8), CNS E18 (RPKM 3.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Kdm4c in Genome Data Viewer
Location:
4 C3; 4 36.06 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (74160734..74324101)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (74242497..74405864)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene FERM domain containing 3 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10543 Neighboring gene STARR-seq mESC enhancer starr_10544 Neighboring gene zinc finger protein 384 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:73965324-73965624 Neighboring gene STARR-seq mESC enhancer starr_10545 Neighboring gene predicted gene, 26379 Neighboring gene predicted gene 11254

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer. Jie X, et al. J Immunother Cancer, 2022 Feb. PMID 35121645, Free PMC Article
  2. Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice. Sudo G, et al. Genes Cells, 2016 Mar. PMID 26805559
  3. The oncogenic role of GASC1 in chemically induced mouse skin cancer. Ozaki Y, et al. Mamm Genome, 2015 Dec. PMID 26248577
  4. Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation. Jung ES, et al. Biochim Biophys Acta, 2015 Aug. PMID 26149774
  5. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Das PP, et al. Mol Cell, 2014 Jan 9. PMID 24361252, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KDM4C promotes mouse hippocampal neural stem cell proliferation through modulating ApoE expression.
    Title: KDM4C promotes mouse hippocampal neural stem cell proliferation through modulating ApoE expression.
  2. The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells.
    Title: The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.
  3. Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
    Title: Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
  4. Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
    Title: Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
  5. Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.
    Title: Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.
  6. KDM4 knockdown resulted in the down-regulation of miR-29 expression.
    Title: The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.
  7. LSD1 and JMJD2C disable oncogenic Ras- or Braf-induced senescence by enabling the expression of E2F target genes
    Title: Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
  8. Jmjd2c and G9a are novel enhancer-associated factors; Jmjd2c is a molecular scaffold for the assembly of essential enhancer-protein complexes with an impact on timely gene activation
    Title: Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.
  9. The authors show that Jmjd2a and Jmjd2c both localize to H3K4me3-positive promoters, where they have widespread and redundant roles in preventing accumulation of H3K9me3 and H3K36me3.
    Title: Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.
  10. Number of GFAP-positive astrocytes in the brain of Gasc1 hypomorphic mutant mice is increased at 2-3 months of age.
    Title: Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables H3K9me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K36 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 demethylase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H3K9me2/H3K9me3 demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9me2/H3K9me3 demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stem cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysine-specific demethylase 4C
Names
[histone H3]-trimethyl-L-lysine(9) demethylase 4C
gene amplified in squamous cell carcinoma 1
jmjC domain-containing histone demethylation protein 3C
jumonji domain containing 2C
jumonji domain-containing protein 2C
NP_001165566.1
NP_001343490.1
NP_659036.1
XP_006538414.1
XP_006538415.1
XP_030109752.1
XP_030109753.1
XP_036020428.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172095.1 → NP_001165566.1  lysine-specific demethylase 4C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    BC042424, BF019842
    UniProtKB/Swiss-Prot
    Q8VCD7
    Conserved Domains (4) summary
    smart00333
    Location:892 → 948
    TUDOR; Tudor domain
    pfam02373
    Location:194 → 310
    JmjC; JmjC domain, hydroxylase
    cl15840
    Location:33 → 74
    JmjN; jmjN domain
    cl22851
    Location:770 → 879
    PHD_SF; PHD finger superfamily

  2. NM_001356561.1 → NP_001343490.1  lysine-specific demethylase 4C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK042792, AK173023, BF019842
    Conserved Domains (3) summary
    pfam02373
    Location:102 → 218
    JmjC; JmjC domain, hydroxylase
    pfam18104
    Location:805 → 839
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl22851
    Location:678 → 787
    PHD_SF; PHD finger superfamily

  3. NM_144787.2 → NP_659036.1  lysine-specific demethylase 4C isoform 1

    See identical proteins and their annotated locations for NP_659036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK173023, BF019842
    Consensus CDS
    CCDS18287.1
    UniProtKB/Swiss-Prot
    Q3UNP7, Q69ZZ5, Q8BUY6, Q8BWA1, Q8VCD7
    UniProtKB/TrEMBL
    A2BEG5
    Related
    ENSMUSP00000030102.6, ENSMUST00000030102.12
    Conserved Domains (5) summary
    cd15715
    Location:753 → 862
    ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    pfam18104
    Location:880 → 914
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl15840
    Location:16 → 57
    JmjN; jmjN domain
    cl22851
    Location:643 → 744
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    74160734..74324101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164535.1 → XP_036020428.1  lysine-specific demethylase 4C isoform X3

    Conserved Domains (4) summary
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cl02573
    Location:877 → 925
    Tudor_SF; Tudor domain superfamily
    cl15840
    Location:16 → 57
    JmjN; jmjN domain
    cl22851
    Location:753 → 862
    PHD_SF; PHD finger superfamily

  2. XM_030253892.1 → XP_030109752.1  lysine-specific demethylase 4C isoform X4

    Conserved Domains (3) summary
    pfam02373
    Location:1 → 112
    JmjC; JmjC domain, hydroxylase
    pfam18104
    Location:699 → 733
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl22851
    Location:572 → 681
    PHD_SF; PHD finger superfamily

  3. XM_030253893.1 → XP_030109753.1  lysine-specific demethylase 4C isoform X4

    Conserved Domains (3) summary
    pfam02373
    Location:1 → 112
    JmjC; JmjC domain, hydroxylase
    pfam18104
    Location:699 → 733
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl22851
    Location:572 → 681
    PHD_SF; PHD finger superfamily

  4. XM_006538352.5 → XP_006538415.1  lysine-specific demethylase 4C isoform X2

    See identical proteins and their annotated locations for XP_006538415.1

    UniProtKB/Swiss-Prot
    Q3UNP7, Q69ZZ5, Q8BUY6, Q8BWA1, Q8VCD7
    UniProtKB/TrEMBL
    A2BEG5
    Conserved Domains (5) summary
    cd15715
    Location:753 → 862
    ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    pfam18104
    Location:880 → 914
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl15840
    Location:16 → 57
    JmjN; jmjN domain
    cl22851
    Location:643 → 744
    PHD_SF; PHD finger superfamily

  5. XM_006538351.2 → XP_006538414.1  lysine-specific demethylase 4C isoform X1

    See identical proteins and their annotated locations for XP_006538414.1

    Conserved Domains (3) summary
    pfam02373
    Location:102 → 218
    JmjC; JmjC domain, hydroxylase
    pfam18104
    Location:805 → 839
    Tudor_2; Jumonji domain-containing protein 2A Tudor domain
    cl22851
    Location:678 → 787
    PHD_SF; PHD finger superfamily

RNA

  1. XR_004942008.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCD7.1 GenPept UniProtKB/Swiss-Prot:Q8VCD7

Gene LinkOut

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