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Klhdc10 kelch domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 76788, updated on 11-Apr-2024

Summary

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Official Symbol
Klhdc10provided by MGI
Official Full Name
kelch domain containing 10provided by MGI
Primary source
MGI:MGI:1924038
See related
Ensembl:ENSMUSG00000029775 AllianceGenome:MGI:1924038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0265; 2410127E18Rik
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 31.1), whole brain E14.5 (RPKM 31.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.52 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30401516..30455178)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30401517..30455179)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene zinc finger, C3HC type 1 Neighboring gene STARR-positive B cell enhancer ABC_E6420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30351601-30351833 Neighboring gene RIKEN cDNA 1700012C14 gene Neighboring gene transmembrane protein 209 Neighboring gene STARR-seq mESC enhancer starr_15468

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation. Yamaguchi N, et al. PLoS One, 2016. PMID 27631783, Free PMC Article
  2. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0265

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311087.1 → NP_001298016.1  kelch domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001298016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK085116, BC056496, CJ134796
    Consensus CDS
    CCDS80509.1
    UniProtKB/Swiss-Prot
    Q6PAR0
    Related
    ENSMUSP00000064594.7, ENSMUST00000068240.13
    Conserved Domains (4) summary
    PLN02153
    Location:107 → 270
    PLN02153; epithiospecifier protein
    PRK14131
    Location:56 → 139
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:176 → 224
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:283 → 329
    Kelch_1; Kelch motif

  2. NM_029742.3 → NP_084018.1  kelch domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_084018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC056496, BC060132, CJ134796
    Consensus CDS
    CCDS19971.1
    UniProtKB/Swiss-Prot
    Q6A095, Q6PAR0, Q8BH94, Q8BPK7, Q8C3Q4, Q8C7G4, Q9CWF4
    Related
    ENSMUSP00000069669.7, ENSMUST00000068259.10
    Conserved Domains (4) summary
    PLN02153
    Location:136 → 299
    PLN02153; epithiospecifier protein
    PRK14131
    Location:85 → 168
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:205 → 253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:312 → 358
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30401516..30455178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255666.1 → XP_030111526.1  kelch domain-containing protein 10 isoform X2

    Conserved Domains (2) summary
    PLN02153
    Location:40 → 201
    PLN02153; epithiospecifier protein
    sd00038
    Location:54 → 100
    Kelch; KELCH repeat [structural motif]

  2. XM_017321829.2 → XP_017177318.1  kelch domain-containing protein 10 isoform X1

    Conserved Domains (4) summary
    PLN02153
    Location:132 → 295
    PLN02153; epithiospecifier protein
    PRK14131
    Location:81 → 164
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:201 → 249
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:308 → 354
    Kelch_1; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PAR0.1 GenPept UniProtKB/Swiss-Prot:Q6PAR0

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