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Ppfia3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 76787, updated on 5-Mar-2024

Summary

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Official Symbol
Ppfia3provided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3provided by MGI
Primary source
MGI:MGI:1924037
See related
Ensembl:ENSMUSG00000003863 AllianceGenome:MGI:1924037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410127E16Rik
Summary
Involved in synaptic vesicle docking. Located in acrosomal vesicle; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in nervous system; nose; and retina layer. Orthologous to human PPFIA3 (PTPRF interacting protein alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 33.6), frontal lobe adult (RPKM 25.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.26 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44988550..45016443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45339126..45367019, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 4 Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene histidine rich calcium binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2237 Neighboring gene STARR-positive B cell enhancer ABC_E700 Neighboring gene STARR-positive B cell enhancer ABC_E11352 Neighboring gene metastasis associated gene 2 Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene small nuclear ribonucleoprotein 70 (U1)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure. Emperador-Melero J, et al. Nat Commun, 2021 May 24. PMID 34031393, Free PMC Article
  2. Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α. Wakita M, et al. Nat Commun, 2020 Jan 31. PMID 32005855, Free PMC Article
  3. Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function. Brenig J, et al. J Biol Chem, 2015 Jun 5. PMID 25911102, Free PMC Article
  4. Liprin α3: a putative estrogen regulated acrosomal protein. Joshi CS, et al. Histochem Cell Biol, 2013 Apr. PMID 23124857
  5. Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Wong MY, et al. Proc Natl Acad Sci U S A, 2018 Feb 27. PMID 29439199, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKC-phosphorylation of Liprin-alpha3 triggers phase separation and controls presynaptic active zone structure.
    Title: PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.
  2. PTPdelta D2 interacts with the N-terminal helix and the first and second SAMs (SAM1 and SAM2, respectively) of Liprin-alpha3.
    Title: Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α.
  3. Liprin-alpha3 has important roles in active-zone assembly and function; interplay between various Liprin-alpha proteins controls their active-zone localization
    Title: Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses.
  4. Liprin-alpha3 uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 activation by RhoA.
    Title: Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle docking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle docking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in epididymosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
liprin-alpha-3
Names
Liprin-alpha3
PTPRF-interacting protein alpha-3
protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029741.2 → NP_084017.2  liprin-alpha-3

    See identical proteins and their annotated locations for NP_084017.2

    Status: VALIDATED

    Source sequence(s)
    AK010782, AK147645, AW060329, BC058404
    Consensus CDS
    CCDS52246.1
    UniProtKB/Swiss-Prot
    B8QI35, P60469
    UniProtKB/TrEMBL
    C7G3P1
    Related
    ENSMUSP00000003961.9, ENSMUST00000003961.16
    Conserved Domains (5) summary
    cd09562
    Location:835 → 905
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:952 → 1017
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1037 → 1108
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:151 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:535 → 747
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44988550..45016443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250914.2 → XP_011249216.1  liprin-alpha-3 isoform X2

    UniProtKB/TrEMBL
    C7G3P1
    Conserved Domains (5) summary
    cd09562
    Location:835 → 905
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:943 → 1008
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1028 → 1099
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:151 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:535 → 747
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  2. XM_036153552.1 → XP_036009445.1  liprin-alpha-3 isoform X2

    UniProtKB/TrEMBL
    C7G3P1
    Related
    ENSMUSP00000147584.2, ENSMUST00000210248.2
    Conserved Domains (5) summary
    cd09562
    Location:835 → 905
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:943 → 1008
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1028 → 1099
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:151 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:535 → 747
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  3. XM_006541273.2 → XP_006541336.1  liprin-alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_006541336.1

    UniProtKB/Swiss-Prot
    B8QI35, P60469
    UniProtKB/TrEMBL
    C7G3P1
    Related
    ENSMUST00000210586.2
    Conserved Domains (5) summary
    cd09562
    Location:835 → 905
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:952 → 1017
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1037 → 1108
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:151 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:535 → 747
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  4. XM_036153551.1 → XP_036009444.1  liprin-alpha-3 isoform X1

    UniProtKB/Swiss-Prot
    B8QI35, P60469
    UniProtKB/TrEMBL
    C7G3P1
    Related
    ENSMUST00000210479.2
    Conserved Domains (5) summary
    cd09562
    Location:835 → 905
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:952 → 1017
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1037 → 1108
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:151 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:535 → 747
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  5. XM_011250912.4 → XP_011249214.1  liprin-alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_011249214.1

    UniProtKB/Swiss-Prot
    B8QI35, P60469
    UniProtKB/TrEMBL
    C7G3P1
    Related
    ENSMUSP00000148200.2, ENSMUST00000211067.2
    Conserved Domains (5) summary
    cd09562
    Location:835 → 905
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:952 → 1017
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1037 → 1108
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:151 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:535 → 747
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  6. XM_011250915.4 → XP_011249217.1  liprin-alpha-3 isoform X3

    Conserved Domains (3) summary
    cd09562
    Location:284 → 354
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:401 → 466
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:486 → 557
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60469.2 GenPept UniProtKB/Swiss-Prot:P60469

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