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Ntaq1 N-terminal glutamine amidase 1 [ Mus musculus (house mouse) ]

Gene ID: 76773, updated on 5-Mar-2024

Summary

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Official Symbol
Ntaq1provided by MGI
Official Full Name
N-terminal glutamine amidase 1provided by MGI
Primary source
MGI:MGI:1924023
See related
Ensembl:ENSMUSG00000022359 AllianceGenome:MGI:1924023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdyhv1; 2410187C16Rik
Summary
Enables protein-N-terminal glutamine amidohydrolase activity. Involved in cellular protein modification process. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human NTAQ1 (N-terminal glutamine amidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 6.7), limb E14.5 (RPKM 6.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ntaq1 in Genome Data Viewer
Location:
15 D1; 15 24.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58004730..58022050)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58141335..58158654)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene STARR-positive B cell enhancer ABC_E941 Neighboring gene ATPase family, AAA domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57966689-57966916 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene STARR-positive B cell enhancer ABC_E3140 Neighboring gene predicted gene, 23475 Neighboring gene predicted gene, 22488 Neighboring gene STARR-seq mESC enhancer starr_38749 Neighboring gene predicted gene, 36112 Neighboring gene F-box protein 32 Neighboring gene predicted gene, 36193

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway. Piatkov KI, et al. Mol Cell, 2012 Dec 28. PMID 23159736, Free PMC Article
  2. Glutamine-specific N-terminal amidase, a component of the N-end rule pathway. Wang H, et al. Mol Cell, 2009 Jun 26. PMID 19560421, Free PMC Article
  3. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. Kole C, et al. PLoS One, 2016. PMID 26985665, Free PMC Article
  4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables protein-N-terminal asparagine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-N-terminal glutamine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-N-terminal glutamine amidohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein modification process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein N-terminal glutamine amidohydrolase
Names
N-terminal Gln amidase
WDYHV motif containing 1
WDYHV motif-containing protein 1
nt(Q)-amidase
protein NH2-terminal glutamine deamidase
NP_001313528.1
NP_001313531.1
NP_084010.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326599.1 → NP_001313528.1  protein N-terminal glutamine amidohydrolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and stop codon, compared to variant 1. It encodes isoform 2, which contains a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113292, AK010831, FO710768
    Consensus CDS
    CCDS88766.1
    UniProtKB/TrEMBL
    Q9CWD7
    Related
    ENSMUSP00000154671.2, ENSMUST00000227142.2
    Conserved Domains (1) summary
    pfam09764
    Location:25 → 171
    Nt_Gln_amidase; N-terminal glutamine amidase

  2. NM_001326602.1 → NP_001313531.1  protein N-terminal glutamine amidohydrolase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate splice site and lacks two alternate exons in the 3' region, resulting in a frameshift compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI843652, AK167510, FO710768
    Consensus CDS
    CCDS88767.1
    UniProtKB/TrEMBL
    A0A2I3BQY8
    Related
    ENSMUSP00000154254.2, ENSMUST00000226955.2

  3. NM_029734.2 → NP_084010.1  protein N-terminal glutamine amidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_084010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI843652, AK150578, FO710768
    Consensus CDS
    CCDS27490.1
    UniProtKB/Swiss-Prot
    Q80WB5
    Related
    ENSMUSP00000064622.8, ENSMUST00000067563.9
    Conserved Domains (1) summary
    pfam09764
    Location:25 → 194
    Nt_Gln_amidase; N-terminal glutamine amidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58004730..58022050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001781578.2 RNA Sequence

  2. XR_003951445.2 RNA Sequence

  3. XR_001781577.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WB5.1 GenPept UniProtKB/Swiss-Prot:Q80WB5

Gene LinkOut

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Chemical Information
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