U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mospd2 motile sperm domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 76763, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mospd2provided by MGI
Official Full Name
motile sperm domain containing 2provided by MGI
Primary source
MGI:MGI:1924013
See related
Ensembl:ENSMUSG00000061778 AllianceGenome:MGI:1924013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410013I23Rik
Summary
Predicted to be involved in positive regulation of monocyte chemotaxis and positive regulation of neutrophil chemotaxis. Predicted to act upstream of or within chemotaxis. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-endosome membrane contact site. Predicted to be integral component of plasma membrane. Is expressed in Meckel's cartilage and skeleton. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 8.6), limb E14.5 (RPKM 5.1) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mospd2 in Genome Data Viewer
Location:
X F5; X 76.75 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163719165..163763501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164936169..164980505, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 9 Neighboring gene STARR-seq mESC enhancer starr_48241 Neighboring gene STARR-seq mESC enhancer starr_48242 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48243 Neighboring gene STARR-positive B cell enhancer mm9_chrX:161418402-161418703 Neighboring gene STARR-seq mESC enhancer starr_48245 Neighboring gene macrophage migration inhibitory factor, pseudogene 13 Neighboring gene Fanconi anemia, complementation group B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MOSPD2 is a therapeutic target for the treatment of CNS inflammation. Yacov N, et al. Clin Exp Immunol, 2020 Aug. PMID 32353176, Free PMC Article
  2. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
    Title: MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FFAT motif binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-endosome membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-endosome membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
motile sperm domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290523.1 → NP_001277452.1  motile sperm domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK031405, AK035985, AL669950, AL732426
    Consensus CDS
    CCDS72467.1
    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Related
    ENSMUSP00000107867.3, ENSMUST00000112248.9
    Conserved Domains (2) summary
    pfam00635
    Location:327 → 431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 234
    CRAL_TRIO; CRAL/TRIO domain

  2. NM_001290524.1 → NP_001277453.1  motile sperm domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001277453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, which results in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK031405, AK035985, AL669950, AL732426
    Consensus CDS
    CCDS72468.1
    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Related
    ENSMUSP00000107866.3, ENSMUST00000112247.9
    Conserved Domains (2) summary
    pfam00635
    Location:327 → 431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 234
    CRAL_TRIO; CRAL/TRIO domain

  3. NM_029730.4 → NP_084006.2  motile sperm domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK031405, AK035985, AL669950, AL732426
    Consensus CDS
    CCDS53241.1
    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    UniProtKB/TrEMBL
    B1AU74
    Related
    ENSMUSP00000004715.2, ENSMUST00000004715.2
    Conserved Domains (2) summary
    pfam00635
    Location:327 → 431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 234
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    163719165..163763501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251516.1 → XP_030107376.1  motile sperm domain-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:335 → 439
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:101 → 242
    CRAL_TRIO; CRAL/TRIO domain

  2. XM_030251517.2 → XP_030107377.1  motile sperm domain-containing protein 2 isoform X7

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:335 → 439
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:101 → 242
    CRAL_TRIO; CRAL/TRIO domain

  3. XM_011247875.3 → XP_011246177.1  motile sperm domain-containing protein 2 isoform X4

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:338 → 442
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:101 → 245
    CRAL_TRIO; CRAL/TRIO domain

  4. XM_011247876.3 → XP_011246178.1  motile sperm domain-containing protein 2 isoform X6

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:338 → 442
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:101 → 245
    CRAL_TRIO; CRAL/TRIO domain

  5. XM_006528985.4 → XP_006529048.1  motile sperm domain-containing protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:330 → 434
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93 → 237
    CRAL_TRIO; CRAL/TRIO domain

  6. XM_011247874.3 → XP_011246176.1  motile sperm domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:335 → 439
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:101 → 242
    CRAL_TRIO; CRAL/TRIO domain

  7. XM_011247873.3 → XP_011246175.1  motile sperm domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BYF8, Q8BZB6, Q8C0G1, Q8R0T7, Q9CWP6
    Conserved Domains (2) summary
    pfam00635
    Location:338 → 442
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:101 → 245
    CRAL_TRIO; CRAL/TRIO domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWP6.2 GenPept UniProtKB/Swiss-Prot:Q9CWP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous