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ZNF121 zinc finger protein 121 [ Homo sapiens (human) ]

Gene ID: 7675, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF121provided by HGNC
Official Full Name
zinc finger protein 121provided by HGNC
Primary source
HGNC:HGNC:12904
See related
Ensembl:ENSG00000197961 MIM:194628; AllianceGenome:HGNC:12904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZHC32; ZNF20; D19S204
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 3.6), spleen (RPKM 3.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9560329..9584504, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9686517..9710677, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9671005..9695180, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 426 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9648627-9649362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13931 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:9650343-9651542 Neighboring gene ZNF426 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr19:9677059-9677560 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9692318-9693131 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9693132-9693944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9694759-9695570 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9700111-9700757 Neighboring gene uncharacterized LOC105376914 Neighboring gene zinc finger protein 561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9731087-9731669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13932

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. Chen H, et al. Genomics, 1993 Mar. PMID 8468057
  2. Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells. Luo A, et al. J Genet Genomics, 2016 Dec 20. PMID 27988300
  3. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. Liu W, et al. Biochem Biophys Res Commun, 2018 Jun 12. PMID 29698681
  4. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Ohira M, et al. Oncogene, 2003 Aug 21. PMID 12934113
  5. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Koch HB, et al. Cell Cycle, 2007 Jan 15. PMID 17314511

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.
    Title: Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.
  2. ZNF121 as a MYC-interacting protein with functional effects on MYC and cell proliferation
    Title: Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 121
Names
zinc finger protein 121 (clone ZHC32)
zinc finger protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008727.5 → NP_001008727.1  zinc finger protein 121

    See identical proteins and their annotated locations for NP_001008727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region resulting in use of an alternate start codon compared to variant 1. Variants 1 and 2 encode the same protein sequence.
    Source sequence(s)
    AC008567, AC008759, AU253046
    Consensus CDS
    CCDS32902.1
    UniProtKB/Swiss-Prot
    P58317
    Related
    ENSP00000326967.5, ENST00000320451.7
    Conserved Domains (4) summary
    COG5048
    Location:226 → 388
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:144 → 166
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:158 → 182
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001308269.3 → NP_001295198.1  zinc finger protein 121

    See identical proteins and their annotated locations for NP_001295198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein sequence.
    Source sequence(s)
    AA096354, AC008567, AW949690, BF763738, CN360954, CN360955, DC424100
    Consensus CDS
    CCDS77228.1
    UniProtKB/Swiss-Prot
    P58317
    Related
    ENSP00000468643.1, ENST00000586602.5
    Conserved Domains (4) summary
    COG5048
    Location:226 → 388
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:144 → 166
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:158 → 182
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9560329..9584504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027239.2 → XP_016882728.1  zinc finger protein 121 isoform X1

    UniProtKB/Swiss-Prot
    P58317
    Conserved Domains (4) summary
    COG5048
    Location:226 → 388
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:144 → 166
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:158 → 182
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9686517..9710677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322001.1 → XP_054177976.1  zinc finger protein 121 isoform X1

    UniProtKB/Swiss-Prot
    P58317
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58317.2 GenPept UniProtKB/Swiss-Prot:P58317

Gene LinkOut

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