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Cpb1 carboxypeptidase B1 [ Mus musculus (house mouse) ]

Gene ID: 76703, updated on 5-Mar-2024

Summary

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Official Symbol
Cpb1provided by MGI
Official Full Name
carboxypeptidase B1provided by MGI
Primary source
MGI:MGI:1923953
See related
Ensembl:ENSMUSG00000011463 AllianceGenome:MGI:1923953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0910001A18Rik; 1810063F02Rik; 2210008M23Rik
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in alimentary system; brain; genitourinary system; thymus; and trachea. Orthologous to human CPB1 (carboxypeptidase B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 332.2), spleen adult (RPKM 215.9) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Cpb1 in Genome Data Viewer
Location:
3 A2; 3 6.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (20303643..20339681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (20249479..20275733, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31320 Neighboring gene microRNA 7007 Neighboring gene carboxypeptidase A3, mast cell Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07114 Neighboring gene angiotensin II receptor, type 1b Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. Chatterjee S, et al. J Immunol, 2009 Sep 15. PMID 19717511, Free PMC Article
  2. The gene mutated in cocoa mice, carrying a defect of organelle biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3 gene. Suzuki T, et al. Genomics, 2001 Nov. PMID 11707070
  3. von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation. Soggia A, et al. Diabetologia, 2014 Nov. PMID 25186293
  4. The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Hale MA, et al. Development, 2014 Aug. PMID 25063451, Free PMC Article
  5. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CPB1 colocalization, coupling, and proximity to NOS-3 in the sinus-lining cells of spleen red pulp could explain the site-specific tyrosine nitration and inactivation of CPB1
    Title: Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase B
Names
carboxypeptidase B1 (tissue)
NP_083982.1
XP_036019285.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029706.2 → NP_083982.1  carboxypeptidase B precursor

    See identical proteins and their annotated locations for NP_083982.1

    Status: VALIDATED

    Source sequence(s)
    AC158937, AK003061, AK008678, BQ831426
    Consensus CDS
    CCDS17263.1
    UniProtKB/TrEMBL
    B2RS76
    Related
    ENSMUSP00000011607.6, ENSMUST00000011607.6
    Conserved Domains (2) summary
    cd03871
    Location:112 → 411
    M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
    pfam02244
    Location:31 → 102
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    20303643..20339681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163392.1 → XP_036019285.1  carboxypeptidase B isoform X1

    UniProtKB/TrEMBL
    B2RS76
    Conserved Domains (2) summary
    cd03871
    Location:112 → 411
    M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
    pfam02244
    Location:31 → 102
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein Strain
Heading Accession and Version

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