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Arfrp1 ADP-ribosylation factor related protein 1 [ Mus musculus (house mouse) ]

Gene ID: 76688, updated on 21-Apr-2024

Summary

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Official Symbol
Arfrp1provided by MGI
Official Full Name
ADP-ribosylation factor related protein 1provided by MGI
Primary source
MGI:MGI:1923938
See related
Ensembl:ENSMUSG00000038671 AllianceGenome:MGI:1923938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500006I01Rik
Summary
The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in CNS E14 (RPKM 16.3), CNS E18 (RPKM 14.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 103.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180999483..181007197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181357690..181365404, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10172 Neighboring gene STARR-seq mESC enhancer starr_06749 Neighboring gene stathmin-like 3 Neighboring gene STARR-seq mESC enhancer starr_06750 Neighboring gene STARR-seq mESC enhancer starr_06751 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4532 Neighboring gene STARR-positive B cell enhancer ABC_E11178 Neighboring gene zinc finger, CCCH-type with G patch domain Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene Slc2a4 regulator, pseudogene Neighboring gene Lck interacting transmembrane adaptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Zhang Z, et al. Nat Immunol, 2023 Jan. PMID 36443515, Free PMC Article
  2. The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Hommel A, et al. Mol Cell Biol, 2010 Mar. PMID 20038528, Free PMC Article
  3. Distribution of ADP-ribosylation factor-related protein 1 in mouse brain. Paratore S, et al. Arch Ital Biol, 2008 Mar. PMID 18666447
  4. Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly. Hesse D, et al. J Lipid Res, 2014 Jan. PMID 24186947, Free PMC Article
  5. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Jaschke A, et al. Hum Mol Genet, 2012 Jul 15. PMID 22505585, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic beta-cells.
    Title: The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
  2. ARFRP1 and the Golgi apparatus play an important role in lipoprotein maturation in the liver.
    Title: Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly.
  3. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
    Title: The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
  4. data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 secretion and GLUT2 sorting and is thereby essential for normal growth and glycogen storage
    Title: GTPase ARFRP1 is essential for normal hepatic glycogen storage and insulin-like growth factor 1 secretion.
  5. Arfrp1 appears to be involved in sorting of GLUT4.
    Title: Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.
  6. Lipid droplets of adipocytes of Arfrp1(-/-) mice were smaller and exhibited ultrastructural alterations, such as a disturbed interaction of small lipid particles with larger droplets.
    Title: The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis.
  7. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin.
    Title: ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin.
  8. This study provides the first detailed analysis of the regional distribution of ARFRP1 in the mouse brain and a quantitative view of its changes following sleep deprivation.
    Title: Distribution of ADP-ribosylation factor-related protein 1 in mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6837

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-related protein 1
Names
ARF-related protein 1
NP_001159463.1
NP_001159464.1
NP_001159467.1
NP_083978.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165991.1 → NP_001159463.1  ADP-ribosylation factor-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001159463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK005174, AL928965, BB770913, BC046786
    Consensus CDS
    CCDS17209.1
    UniProtKB/Swiss-Prot
    Q8BXL7
    Related
    ENSMUSP00000104436.2, ENSMUST00000108808.8
    Conserved Domains (1) summary
    cd04160
    Location:19 → 186
    Arfrp1; Arf-related protein 1 (Arfrp1)

  2. NM_001165992.1 → NP_001159464.1  ADP-ribosylation factor-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001159464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL928965
    Consensus CDS
    CCDS17209.1
    UniProtKB/Swiss-Prot
    Q8BXL7
    Conserved Domains (1) summary
    cd04160
    Location:19 → 186
    Arfrp1; Arf-related protein 1 (Arfrp1)

  3. NM_001165995.1 → NP_001159467.1  ADP-ribosylation factor-related protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001159467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region that results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL928965
    Consensus CDS
    CCDS50853.1
    UniProtKB/TrEMBL
    E9PZK7
    Related
    ENSMUSP00000126387.2, ENSMUST00000170190.8
    Conserved Domains (1) summary
    cd04160
    Location:1 → 139
    Arfrp1; Arf-related protein 1 (Arfrp1)

  4. NM_029702.4 → NP_083978.3  ADP-ribosylation factor-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_083978.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK005174, AL928965, BB770913, BC046786, CA539216
    Consensus CDS
    CCDS17209.1
    UniProtKB/Swiss-Prot
    Q8BXL7
    Related
    ENSMUSP00000122066.2, ENSMUST00000127988.8
    Conserved Domains (1) summary
    cd04160
    Location:19 → 186
    Arfrp1; Arf-related protein 1 (Arfrp1)

RNA

  1. NR_028585.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL928965, BB770913, BC046786, CA539216
    Related
    ENSMUST00000185118.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180999483..181007197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003953743.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXL7.2 GenPept UniProtKB/Swiss-Prot:Q8BXL7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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