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Clip3 CAP-GLY domain containing linker protein 3 [ Mus musculus (house mouse) ]

Gene ID: 76686, updated on 5-Mar-2024

Summary

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Official Symbol
Clip3provided by MGI
Official Full Name
CAP-GLY domain containing linker protein 3provided by MGI
Primary source
MGI:MGI:1923936
See related
Ensembl:ENSMUSG00000013921 AllianceGenome:MGI:1923936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clipr-59; 1500005P14Rik
Summary
Predicted to enable ganglioside binding activity and microtubule plus-end binding activity. Involved in positive regulation of glucose transmembrane transport; positive regulation of protein localization to plasma membrane; and positive regulation of protein phosphorylation. Acts upstream of or within fat cell differentiation. Located in plasma membrane and trans-Golgi network. Is expressed in several structures, including central nervous system; genitourinary system; and retina layer. Orthologous to human CLIP3 (CAP-Gly domain containing linker protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 110.2), cortex adult (RPKM 66.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Clip3 in Genome Data Viewer
Location:
7 B1; 7 17.37 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29991120..30007792)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30291695..30308367)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5 Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:31065285-31065586 Neighboring gene THAP domain containing 8, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3711 Neighboring gene alkB homolog 6 Neighboring gene spectrin repeat containing, nuclear envelope family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ClipR-59 interacts with Elmo2 and modulates myoblast fusion. Sun Y, et al. J Biol Chem, 2015 Mar 6. PMID 25572395, Free PMC Article
  2. The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation. Ren W, et al. J Biol Chem, 2012 Aug 3. PMID 22689584, Free PMC Article
  3. DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane. Ren W, et al. Mol Cell Biol, 2013 Nov. PMID 24001771, Free PMC Article
  4. CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Couesnon A, et al. Development, 2013 Apr. PMID 23482493
  5. ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Ding J, et al. Mol Cell Biol, 2009 Mar. PMID 19139280, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
    Title: ClipR-59 interacts with Elmo2 and modulates myoblast fusion.
  2. CLIPR-59 is involved in the stabilization of specific motor axons at the neuromuscular junction during mouse late embryogenesis and its role is crucial for mouse perinatal development.
    Title: CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development.
  3. Because ClipR-59 also interacts with Akt and enhances the interaction between Akt and AS160, we suggest that ClipR-59 functions as a scaffold protein to facilitate Akt-mediated AS160 phosphorylation, thereby regulating glucose transport
    Title: The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation.
  4. ClipR-59 functions as a scaffold protein that interacts with phospho-Akt and recruits active Akt on the membrane and may play an important role in adipocyte glucose transport.
    Title: ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ganglioside binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fat cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in membrane biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CAP-Gly domain-containing linker protein 3
Names
CLIP-170-related 59 kDa protein
clip-170 related protein 59 kDa
cytoplasmic linker protein 170-related 59 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081114.2 → NP_001074583.1  CAP-Gly domain-containing linker protein 3

    See identical proteins and their annotated locations for NP_001074583.1

    Status: VALIDATED

    Source sequence(s)
    AC149067
    Consensus CDS
    CCDS39880.1
    UniProtKB/Swiss-Prot
    B9EHT4, Q7TNI1, Q9DB67
    Related
    ENSMUSP00000014065.9, ENSMUST00000014065.16
    Conserved Domains (3) summary
    sd00045
    Location:120 → 157
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:418 → 482
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:122 → 228
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001360763.1 → NP_001347692.1  CAP-Gly domain-containing linker protein 3

    Status: VALIDATED

    Source sequence(s)
    AC149067
    Consensus CDS
    CCDS39880.1
    UniProtKB/Swiss-Prot
    B9EHT4, Q7TNI1, Q9DB67
    Conserved Domains (3) summary
    sd00045
    Location:120 → 157
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:418 → 482
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:122 → 228
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001360764.1 → NP_001347693.1  CAP-Gly domain-containing linker protein 3

    Status: VALIDATED

    Source sequence(s)
    AC149067
    Consensus CDS
    CCDS39880.1
    UniProtKB/Swiss-Prot
    B9EHT4, Q7TNI1, Q9DB67
    Conserved Domains (3) summary
    sd00045
    Location:120 → 157
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:418 → 482
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:122 → 228
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29991120..30007792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9EHT4.1 GenPept UniProtKB/Swiss-Prot:B9EHT4

Gene LinkOut

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