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Trim12a tripartite motif-containing 12A [ Mus musculus (house mouse) ]

Gene ID: 76681, updated on 8-Feb-2024

Summary

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Official Symbol
Trim12aprovided by MGI
Official Full Name
tripartite motif-containing 12Aprovided by MGI
Primary source
MGI:MGI:1923931
See related
Ensembl:ENSMUSG00000066258 AllianceGenome:MGI:1923931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim12; 2310043C01Rik
Summary
Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Located in cytoplasm. Is expressed in bladder and testis. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.6), thymus adult (RPKM 3.8) and 27 other tissues See more
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Genomic context

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See Trim12a in Genome Data Viewer
Location:
7 E3; 7 55.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103949100..103964765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104299893..104315558, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5 Neighboring gene predicted gene, 57517 Neighboring gene STARR-positive B cell enhancer ABC_E875 Neighboring gene STARR-positive B cell enhancer ABC_E2839 Neighboring gene STARR-positive B cell enhancer ABC_E6579 Neighboring gene STARR-positive B cell enhancer ABC_E2840 Neighboring gene STARR-positive B cell enhancer ABC_E876 Neighboring gene predicted gene 15133 Neighboring gene predicted gene, 17788 Neighboring gene tripartite motif-containing 34B Neighboring gene tripartite motif-containing 12C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Copy number variation influences gene expression and metabolic traits in mice. Orozco LD, et al. Hum Mol Genet, 2009 Nov 1. PMID 19648292, Free PMC Article
  2. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Blackburn AC, et al. Am J Pathol, 2007 Jun. PMID 17525270, Free PMC Article
  3. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article
  4. Postnatal gene expression in the normal mouse cornea by SAGE. Norman B, et al. Invest Ophthalmol Vis Sci, 2004 Feb. PMID 14744882
  5. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with omegasome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 12A
Names
tripartite motif protein 12
tripartite motif-containing 12
tripartite motif-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368753.1 → NP_001355682.1  tripartite motif-containing protein 12A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC142110
    UniProtKB/TrEMBL
    Q504P5
    Conserved Domains (3) summary
    pfam08317
    Location:132 → 209
    Spc7; Spc7 kinetochore protein
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001368754.1 → NP_001355683.1  tripartite motif-containing protein 12A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC142110
    Consensus CDS
    CCDS90296.1
    UniProtKB/Swiss-Prot
    Q99PQ1, Q9D704
    Related
    ENSMUSP00000065008.7, ENSMUST00000070943.7
    Conserved Domains (4) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    COG5432
    Location:6 → 112
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    pfam07888
    Location:128 → 251
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. NM_023835.2 → NP_076324.2  tripartite motif-containing protein 12A isoform 2

    See identical proteins and their annotated locations for NP_076324.2

    Status: VALIDATED

    Source sequence(s)
    AC142110, AK009769, DV553257
    Consensus CDS
    CCDS40067.1
    UniProtKB/TrEMBL
    A0A0R4J1B5
    Related
    ENSMUSP00000102452.3, ENSMUST00000106839.9
    Conserved Domains (3) summary
    COG4372
    Location:119 → 297
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103949100..103964765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312375.3 → XP_017167864.1  tripartite motif-containing protein 12A isoform X2

    UniProtKB/TrEMBL
    D3YVI1
    Related
    ENSMUSP00000102450.2, ENSMUST00000106837.8
    Conserved Domains (3) summary
    cd00162
    Location:15 → 58
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_030243083.2 → XP_030098943.1  tripartite motif-containing protein 12A isoform X3

    UniProtKB/TrEMBL
    Q504P5
    Conserved Domains (3) summary
    pfam08317
    Location:132 → 209
    Spc7; Spc7 kinetochore protein
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_030243081.2 → XP_030098941.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (3) summary
    COG4372
    Location:119 → 297
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_017312372.3 → XP_017167861.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (3) summary
    COG4372
    Location:119 → 297
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  5. XM_030243080.2 → XP_030098940.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (3) summary
    COG4372
    Location:119 → 297
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. XM_017312373.3 → XP_017167862.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (3) summary
    COG4372
    Location:119 → 297
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  7. XM_030243082.2 → XP_030098942.1  tripartite motif-containing protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A0R4J1B5
    Conserved Domains (3) summary
    COG4372
    Location:119 → 297
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PQ1.1 GenPept UniProtKB/Swiss-Prot:Q99PQ1

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