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Stambpl1 STAM binding protein like 1 [ Mus musculus (house mouse) ]

Gene ID: 76630, updated on 11-Apr-2024

Summary

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Official Symbol
Stambpl1provided by MGI
Official Full Name
STAM binding protein like 1provided by MGI
Primary source
MGI:MGI:1923880
See related
Ensembl:ENSMUSG00000024776 AllianceGenome:MGI:1923880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AMSH-FP; ALMalpha; 1700095N21Rik; 8230401J17Rik
Summary
Predicted to enable Lys63-specific deubiquitinase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein K63-linked deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in endosome and membrane. Is expressed in alimentary system; central nervous system; dorsal root ganglion; and limb. Orthologous to human STAMBPL1 (STAM binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.7), thymus adult (RPKM 5.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C1; 19 29.35 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34169629..34217733)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34190378..34240333)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lipase, family member N Neighboring gene STARR-seq mESC enhancer starr_45988 Neighboring gene STARR-seq mESC enhancer starr_45989 Neighboring gene lipase, family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene STARR-seq mESC enhancer starr_45990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:34255778-34255996 Neighboring gene STARR-positive B cell enhancer ABC_E5696 Neighboring gene STARR-seq mESC enhancer starr_45992 Neighboring gene actin alpha 2, smooth muscle, aorta Neighboring gene predicted gene, 31355

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells. Kitajima K, et al. Biochem Biophys Res Commun, 2003 Sep 12. PMID 12943674
  2. A novel transcript encoding truncated LIM kinase 2 is specifically expressed in male germ cells undergoing meiosis. Takahashi H, et al. Biochem Biophys Res Commun, 1998 Aug 10. PMID 9705845
  3. An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. Lavorgna A, et al. J Virol, 2012 Mar. PMID 22258247, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AMSH-FP is specifically expressed in haploid stages of testicular germ cells and has a functional role in spermiogenesis [AMSH-FP]
    Title: A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AMSH-like protease
Names
AMSH-LP
AMSH-family protein
NP_001347645.1
NP_001347646.1
NP_001347647.1
NP_001347648.1
NP_001347649.1
NP_083958.3
XP_006527514.1
XP_006527515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360716.1 → NP_001347645.1  AMSH-like protease isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB010121, AC102285, AC165239, AK138126
    Consensus CDS
    CCDS29756.1
    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Related
    ENSMUSP00000159218.2, ENSMUST00000239240.2
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain

  2. NM_001360717.1 → NP_001347646.1  AMSH-like protease isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102285, AC165239
    Consensus CDS
    CCDS29756.1
    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain

  3. NM_001360718.1 → NP_001347647.1  AMSH-like protease isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102285, AC165239
    Consensus CDS
    CCDS29756.1
    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain

  4. NM_001360719.1 → NP_001347648.1  AMSH-like protease isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102285
    Consensus CDS
    CCDS29756.1
    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Related
    ENSMUSP00000112938.2, ENSMUST00000119603.2
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain

  5. NM_001360720.1 → NP_001347649.1  AMSH-like protease isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102285, AK007087
    Conserved Domains (1) summary
    cd08066
    Location:100 → 270
    MPN_AMSH_like; Mov34/MPN/PAD-1 family

  6. NM_029682.5 → NP_083958.3  AMSH-like protease isoform 1

    See identical proteins and their annotated locations for NP_083958.3

    Status: VALIDATED

    Source sequence(s)
    AB010121, AC102285, AC165239
    Consensus CDS
    CCDS29756.1
    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Related
    ENSMUSP00000059927.9, ENSMUST00000054956.15
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34169629..34217733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527452.5 → XP_006527515.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_006527515.1

    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain

  2. XM_006527451.5 → XP_006527514.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_006527514.1

    UniProtKB/Swiss-Prot
    Q76LY0, Q76N33, Q8VEK5
    Conserved Domains (3) summary
    cd08066
    Location:266 → 436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:119 → 195
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]
    pfam08969
    Location:28 → 129
    USP8_dimer; USP8 dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76N33.1 GenPept UniProtKB/Swiss-Prot:Q76N33

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