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Ipo11 importin 11 [ Mus musculus (house mouse) ]

Gene ID: 76582, updated on 21-Apr-2024

Summary

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Official Symbol
Ipo11provided by MGI
Official Full Name
importin 11provided by MGI
Primary source
MGI:MGI:2442377
See related
Ensembl:ENSMUSG00000042590 AllianceGenome:MGI:2442377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ranbp11; 1700081H05Rik; 2510001A17Rik; E330021B14Rik
Summary
Enables nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including early conceptus; gonad; and islets of Langerhans. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.7), CNS E18 (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1- D2.1; 13 58.06 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (106930947..107073466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (106794439..106936958, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35564 Neighboring gene predicted gene, 30411 Neighboring gene Ipo11-lrrc70 readthrough Neighboring gene predicted gene, 24527 Neighboring gene STARR-seq mESC enhancer starr_35565 Neighboring gene leucine rich repeat containing 70 Neighboring gene STARR-seq mESC enhancer starr_35568 Neighboring gene STARR-seq mESC enhancer starr_35569 Neighboring gene predicted gene, 57603 Neighboring gene STARR-seq mESC enhancer starr_35570 Neighboring gene STARR-positive B cell enhancer ABC_E1165 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene kinesin family member 2A Neighboring gene STARR-positive B cell enhancer ABC_E7276 Neighboring gene RIKEN cDNA 3830408C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E11558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Importin-11 is Essential for Normal Embryonic Development in Mice. Lee JY, et al. Int J Med Sci, 2020. PMID 32218703, Free PMC Article
  2. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. Chen M, et al. J Cell Biol, 2017 Mar 6. PMID 28193700, Free PMC Article
  3. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Gu Y, et al. Mol Cancer, 2021 Oct 14. PMID 34649567, Free PMC Article
  4. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Plafker SM, et al. Mol Cell Biol, 2002 Feb. PMID 11809816, Free PMC Article
  5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
    Title: Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (4) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Ipo11-lrrc70

Readthrough gene: Ipo11-lrrc70, Included gene: Lrrc70

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosomal protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
importin-11
Names
imp11
ran-binding protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360897.1 → NP_001347826.1  importin-11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154328, BC031900
    Consensus CDS
    CCDS88519.1
    Related
    ENSMUSP00000140046.2, ENSMUST00000186033.7
    Conserved Domains (2) summary
    sd00044
    Location:426 → 459
    HEAT; HEAT repeat [structural motif]
    cl27876
    Location:10 → 981
    Cse1; Cse1

  2. NM_029665.4 → NP_083941.2  importin-11 isoform 1

    See identical proteins and their annotated locations for NP_083941.2

    Status: VALIDATED

    Source sequence(s)
    AC154328, AC165281
    Consensus CDS
    CCDS36776.1
    UniProtKB/Swiss-Prot
    Q8BU45, Q8K0B4, Q8K2V6
    Related
    ENSMUSP00000079667.8, ENSMUST00000080856.14
    Conserved Domains (3) summary
    COG5657
    Location:10 → 972
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
    pfam03810
    Location:28 → 100
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:426 → 459
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    106930947..107073466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175202.2: Suppressed sequence

    Description
    NM_175202.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2V6.1 GenPept UniProtKB/Swiss-Prot:Q8K2V6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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