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Faf2 Fas associated factor family member 2 [ Mus musculus (house mouse) ]

Gene ID: 76577, updated on 21-Apr-2024

Summary

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Official Symbol
Faf2provided by MGI
Official Full Name
Fas associated factor family member 2provided by MGI
Primary source
MGI:MGI:1923827
See related
Ensembl:ENSMUSG00000025873 AllianceGenome:MGI:1923827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubxd8; mKIAA0887; 2210404D11Rik
Summary
Predicted to enable enzyme binding activity; lipase inhibitor activity; and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum and lipid droplet. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Orthologous to human FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 14.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 28.88 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54769597..54811876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54621784..54664063)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E927 Neighboring gene HIG1 domain family, member 2A Neighboring gene STARR-seq mESC enhancer starr_34588 Neighboring gene STARR-seq mESC enhancer starr_34589 Neighboring gene clathrin light chain B Neighboring gene STARR-seq mESC enhancer starr_34590 Neighboring gene STARR-seq mESC enhancer starr_34591 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene ring finger protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E3083 Neighboring gene cadherin-related family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatocyte-specific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model. Imai N, et al. Histochem Cell Biol, 2017 Sep. PMID 28421320
  2. Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet. Imai N, et al. PLoS One, 2015. PMID 25970332, Free PMC Article
  3. UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. Geng T, et al. mBio, 2022 Dec 20. PMID 36377866, Free PMC Article
  4. UBXN3B positively regulates STING-mediated antiviral immune responses. Yang L, et al. Nat Commun, 2018 Jun 13. PMID 29899553, Free PMC Article
  5. Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Olzmann JA, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297223, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubxn3b(-/-), like Sting(-/-) mice, are highly susceptible to lethal herpes simplex virus 1 (HSV-1) and vesicular stomatitis virus (VSV) infection, which is correlated with deficient immune responses when compared to Ubxn3b(+/+) littermates.
    Title: UBXN3B positively regulates STING-mediated antiviral immune responses.
  2. The results indicate that although UBXD8 functionality can be largely compensated in the normal setting, it is crucial to sustain VLDL secretion when exposed to a dietary challenge of high fat.
    Title: Hepatocyte-specific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model.
  3. Depletion of UBXD8 in hepatocytes suppresses VLDL secretion, and could lead to periportal steatosis when mice are fed a high-fat diet.
    Title: Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipase binding ISO
Inferred from Sequence Orthology
more info
  
enables lipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid droplet organization ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule disassembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FAS-associated factor 2
Names
UBX domain containing 8
UBX domain-containing protein 8
protein expressed in T-cells and eosinophils in atopic dermatitis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178397.3 → NP_848484.2  FAS-associated factor 2

    See identical proteins and their annotated locations for NP_848484.2

    Status: VALIDATED

    Source sequence(s)
    AK148529, BC046817, BY139990
    Consensus CDS
    CCDS36668.1
    UniProtKB/Swiss-Prot
    Q3TDN2, Q3U9W2, Q80TP7, Q80W42
    Related
    ENSMUSP00000121182.2, ENSMUST00000126071.9
    Conserved Domains (3) summary
    cd02991
    Location:154 → 269
    UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
    cd14414
    Location:15 → 52
    UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins
    cd16120
    Location:362 → 441
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54769597..54811876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244582.4 → XP_011242884.1  FAS-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011242884.1

    Conserved Domains (3) summary
    cd02991
    Location:126 → 241
    UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
    cd16120
    Location:334 → 413
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl21463
    Location:1 → 24
    UBA_like_SF; UBA domain-like superfamily

  2. XM_030247458.2 → XP_030103318.1  FAS-associated factor 2 isoform X2

    Conserved Domains (2) summary
    cd16120
    Location:157 → 236
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl00388
    Location:1 → 64
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. XM_030247459.2 → XP_030103319.1  FAS-associated factor 2 isoform X2

    Conserved Domains (2) summary
    cd16120
    Location:157 → 236
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl00388
    Location:1 → 64
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  4. XM_036158220.1 → XP_036014113.1  FAS-associated factor 2 isoform X2

    Conserved Domains (2) summary
    cd16120
    Location:157 → 236
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl00388
    Location:1 → 64
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  5. XM_011244583.4 → XP_011242885.1  FAS-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011242885.1

    Conserved Domains (3) summary
    cd02991
    Location:126 → 241
    UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
    cd16120
    Location:334 → 413
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl21463
    Location:1 → 24
    UBA_like_SF; UBA domain-like superfamily

  6. XM_030247460.2 → XP_030103320.1  FAS-associated factor 2 isoform X2

    Conserved Domains (2) summary
    cd16120
    Location:157 → 236
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl00388
    Location:1 → 64
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  7. XM_006517452.5 → XP_006517515.1  FAS-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006517515.1

    Conserved Domains (3) summary
    cd02991
    Location:126 → 241
    UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
    cd16120
    Location:334 → 413
    UBX_UBXN3B; Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins
    cl21463
    Location:1 → 24
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TDN2.2 GenPept UniProtKB/Swiss-Prot:Q3TDN2

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