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Styxl1 serine/threonine/tyrosine interacting-like 1 [ Mus musculus (house mouse) ]

Gene ID: 76571, updated on 5-Mar-2024

Summary

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Official Symbol
Styxl1provided by MGI
Official Full Name
serine/threonine/tyrosine interacting-like 1provided by MGI
Primary source
MGI:MGI:1923821
See related
Ensembl:ENSMUSG00000019178 AllianceGenome:MGI:1923821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dusp24; Mkstyx; 1700011C14Rik
Summary
Predicted to enable protein phosphatase binding activity; protein phosphatase inhibitor activity; and pseudophosphatase activity. Predicted to be involved in several processes, including negative regulation of phosphoprotein phosphatase activity; negative regulation of stress granule assembly; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be active in mitochondrion. Orthologous to human STYXL1 (serine/threonine/tyrosine interacting like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.2), ovary adult (RPKM 0.7) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 75.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135776074..135807277, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135747220..135778424, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome p450 oxidoreductase Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14588 Neighboring gene STARR-positive B cell enhancer ABC_E9654 Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene STARR-positive B cell enhancer ABC_E6387

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables pseudophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pseudophosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine/tyrosine-interacting-like protein 1
Names
dual specificity phosphatase 24 (putative)
map kinase phosphatase-like protein MK-STYX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289554.1 → NP_001276483.1  serine/threonine/tyrosine-interacting-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK005599, BC045148
    Consensus CDS
    CCDS19745.2
    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000051216.5, ENSMUST00000053906.11
    Conserved Domains (1) summary
    cl28904
    Location:158 → 311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. NM_001289555.1 → NP_001276484.1  serine/threonine/tyrosine-interacting-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK005599, BC045148
    Consensus CDS
    CCDS19745.2
    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000106793.3, ENSMUST00000111163.9
    Conserved Domains (1) summary
    cl28904
    Location:158 → 311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. NM_001289556.1 → NP_001276485.1  serine/threonine/tyrosine-interacting-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001276485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK005858, AK161310, BC045148
    Consensus CDS
    CCDS71679.1
    UniProtKB/TrEMBL
    Q9DAG7
    Related
    ENSMUSP00000106791.3, ENSMUST00000111161.9
    Conserved Domains (1) summary
    cl28904
    Location:14 → 167
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. NM_001289557.1 → NP_001276486.1  serine/threonine/tyrosine-interacting-like protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks two alternate exons, which results in a region containing a frameshift, compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
    Source sequence(s)
    AK161310, BC045148, BF471066
    Consensus CDS
    CCDS71680.1
    UniProtKB/TrEMBL
    D3YZ02
    Related
    ENSMUSP00000106792.2, ENSMUST00000111162.8
    Conserved Domains (1) summary
    cl28904
    Location:103 → 207
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. NM_029659.4 → NP_083935.3  serine/threonine/tyrosine-interacting-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_083935.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC083948, AK161310, BC045148
    Consensus CDS
    CCDS19745.2
    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000106794.3, ENSMUST00000111164.9
    Conserved Domains (1) summary
    cl28904
    Location:158 → 311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135776074..135807277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254884.2 → XP_030110744.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X6

    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000135982.2, ENSMUST00000177559.8
    Conserved Domains (1) summary
    cl28904
    Location:158 → 311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_030254888.2 → XP_030110748.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X11

    UniProtKB/TrEMBL
    Q9DAG7
    Conserved Domains (1) summary
    cl28904
    Location:14 → 167
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_006504519.4 → XP_006504582.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X8

    Conserved Domains (1) summary
    cl28904
    Location:119 → 223
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_006504511.3 → XP_006504574.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:174 → 327
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_017321146.3 → XP_017176635.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158 → 278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_017321153.3 → XP_017176642.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X10

    Conserved Domains (1) summary
    cl28904
    Location:14 → 134
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  7. XM_017321150.3 → XP_017176639.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158 → 278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  8. XM_017321149.3 → XP_017176638.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158 → 278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  9. XM_017321151.3 → XP_017176640.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158 → 278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  10. XM_017321147.3 → XP_017176636.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158 → 278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  11. XM_017321148.3 → XP_017176637.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158 → 278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  12. XM_017321145.3 → XP_017176634.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:170 → 290
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  13. XM_017321144.3 → XP_017176633.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:171 → 291
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  14. XM_017321152.2 → XP_017176641.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X7

    Conserved Domains (1) summary
    cl28904
    Location:119 → 190
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  15. XM_017321143.2 → XP_017176632.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:174 → 294
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  16. XM_036165592.1 → XP_036021485.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X9

    UniProtKB/TrEMBL
    J3QK74

RNA

  1. XR_004942585.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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