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Ift46 intraflagellar transport 46 [ Mus musculus (house mouse) ]

Gene ID: 76568, updated on 21-Apr-2024

Summary

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Official Symbol
Ift46provided by MGI
Official Full Name
intraflagellar transport 46provided by MGI
Primary source
MGI:MGI:1923818
See related
Ensembl:ENSMUSG00000002031 AllianceGenome:MGI:1923818
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c11orf2; 1500035H01Rik
Summary
Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in centrosome and motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; hindlimb; and otocyst. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.0), CNS E14 (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 24.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44683074..44704011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44770456..44792714)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery. Ahmed NT, et al. J Cell Biol, 2008 Oct 20. PMID 18852297, Free PMC Article
  2. Autophagy induction promotes renal cyst growth in polycystic kidney disease. Lee EJ, et al. EBioMedicine, 2020 Oct. PMID 32949996, Free PMC Article
  3. A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. Swiderski RE, et al. PLoS Genet, 2014 Oct. PMID 25340710, Free PMC Article
  4. IFT46 plays an essential role in cilia development. Lee MS, et al. Dev Biol, 2015 Apr 15. PMID 25722189, Free PMC Article
  5. Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. Gouttenoire J, et al. J Biol Chem, 2007 Oct 19. PMID 17720815

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates.
    Title: Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axoneme assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cilium organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cilium-dependent cell motility ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intraciliary transport IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within protein transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
 PubMed 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
intraflagellar transport protein 46 homolog
Names
intraflagellar transport 46 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023831.3 → NP_076320.2  intraflagellar transport protein 46 homolog

    See identical proteins and their annotated locations for NP_076320.2

    Status: PROVISIONAL

    Source sequence(s)
    AK032880
    Consensus CDS
    CCDS23119.1
    UniProtKB/Swiss-Prot
    Q91Z06, Q9DB07, Q9JHT1
    UniProtKB/TrEMBL
    A0A5F8MPR6
    Related
    ENSMUSP00000159011.2, ENSMUST00000239014.2
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44683074..44704011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510671.5 → XP_006510734.1  intraflagellar transport protein 46 homolog isoform X1

    See identical proteins and their annotated locations for XP_006510734.1

    UniProtKB/Swiss-Prot
    Q91Z06, Q9DB07, Q9JHT1
    UniProtKB/TrEMBL
    A0A5F8MPR6
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  2. XM_006510672.5 → XP_006510735.1  intraflagellar transport protein 46 homolog isoform X2

    UniProtKB/TrEMBL
    A0A1L1SR19
    Related
    ENSMUSP00000149271.3, ENSMUST00000214854.3
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 222
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  3. XM_036155404.1 → XP_036011297.1  intraflagellar transport protein 46 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q91Z06, Q9DB07, Q9JHT1
    UniProtKB/TrEMBL
    A0A5F8MPR6
    Related
    ENSMUSP00000113845.2, ENSMUST00000118186.2
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

RNA

  1. XR_001779069.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB07.1 GenPept UniProtKB/Swiss-Prot:Q9DB07

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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