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Commd9 COMM domain containing 9 [ Mus musculus (house mouse) ]

Gene ID: 76501, updated on 5-Mar-2024

Summary

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Official Symbol
Commd9provided by MGI
Official Full Name
COMM domain containing 9provided by MGI
Primary source
MGI:MGI:1923751
See related
Ensembl:ENSMUSG00000027163 AllianceGenome:MGI:1923751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810029F08Rik
Summary
Acts upstream of or within cholesterol homeostasis. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skeleton. Orthologous to human COMMD9 (COMM domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 24.5), whole brain E14.5 (RPKM 24.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E2; 2 54.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101716607..101731984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101886262..101901639)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5948 Neighboring gene TNF receptor-associated factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene proline rich 5 like Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene STARR-seq mESC enhancer starr_05238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101819193-101819405 Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101831937-101832164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101833086-101833410 Neighboring gene predicted gene, 39888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101870916-101871189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101879569-101879838 Neighboring gene predicted gene, 54138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of murine copper homeostasis by members of the COMMD protein family. Singla A, et al. Dis Model Mech, 2021 Jan 1. PMID 33262129, Free PMC Article
  2. Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation. Miyata N, et al. Cell Rep, 2018 Aug 28. PMID 30157428, Free PMC Article
  3. The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Fedoseienko A, et al. Circ Res, 2018 Jun 8. PMID 29545368
  4. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. Li H, et al. J Cell Biol, 2015 Nov 9. PMID 26553930, Free PMC Article
  5. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Bartuzi P, et al. Nat Commun, 2016 Mar 11. PMID 26965651, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased total plasma cholesterol levels are seen in hepatic COMMD9-deficient mice.
    Title: CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COMM domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029635.3 → NP_083911.1  COMM domain-containing protein 9

    See identical proteins and their annotated locations for NP_083911.1

    Status: PROVISIONAL

    Source sequence(s)
    AL929534
    Consensus CDS
    CCDS16465.1
    UniProtKB/Swiss-Prot
    Q3U3J2, Q7TNP5, Q811K2, Q8K2Q0, Q9D8V8
    Related
    ENSMUSP00000028584.8, ENSMUST00000028584.8
    Conserved Domains (2) summary
    cd04757
    Location:90 → 197
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    pfam03081
    Location:10 → 146
    Exo70; Exo70 exocyst complex subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    101716607..101731984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2Q0.3 GenPept UniProtKB/Swiss-Prot:Q8K2Q0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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