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Clasp2 CLIP associating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 76499, updated on 5-Mar-2024

Summary

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Official Symbol
Clasp2provided by MGI
Official Full Name
CLIP associating protein 2provided by MGI
Primary source
MGI:MGI:1923749
See related
Ensembl:ENSMUSG00000033392 AllianceGenome:MGI:1923749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0627; CLASP2beta; 1500004F14Rik; 8030404L10Rik
Summary
Enables microtubule binding activity. Acts upstream of or within cell migration; establishment or maintenance of cell polarity; and negative regulation of microtubule depolymerization. Located in Golgi apparatus; cell leading edge; and microtubule cytoskeleton. Is expressed in early conceptus; nervous system; and oocyte. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.3), cerebellum adult (RPKM 19.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Clasp2 in Genome Data Viewer
Location:
9 F3; 9 64.06 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (113567776..113748765)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (113740077..113919697)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25326 Neighboring gene programmed cell death 6 interacting protein Neighboring gene STARR-seq mESC enhancer starr_25327 Neighboring gene STARR-seq mESC enhancer starr_25328 Neighboring gene predicted gene, 38623 Neighboring gene STARR-seq mESC enhancer starr_25329 Neighboring gene STARR-seq mESC enhancer starr_25330 Neighboring gene predicted gene, 25059 Neighboring gene STARR-positive B cell enhancer ABC_E2309 Neighboring gene predicted gene, 39439 Neighboring gene upstream binding protein 1 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene predicted gene, 36035

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation. Sayas CL, et al. Front Cell Neurosci, 2019. PMID 30787869, Free PMC Article
  2. The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance. Drabek K, et al. Cell Rep, 2012 Oct 25. PMID 23084744
  3. Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes. Shahbazi MN, et al. J Cell Sci, 2017 Feb 15. PMID 28069833, Free PMC Article
  4. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. Shahbazi MN, et al. J Cell Biol, 2013 Dec 23. PMID 24368809, Free PMC Article
  5. Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. Beffert U, et al. J Neurosci, 2012 Oct 3. PMID 23035100, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
    Title: CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
  2. Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.
    Title: Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs.
  3. The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein.
    Title: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.
  4. data reveal that CLASP2 is an essential Reelin effector orchestrating cytoskeleton dynamics during brain development.
    Title: CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.
  5. These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features.
    Title: Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes.
  6. A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
    Title: CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
  7. the functional relationship between Abl and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.
    Title: Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.
  8. The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes.
    Title: CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.
  9. CLASP2 is required for the proper attachment of fibroblasts, HSC-enriched cells, and platelets, indicating a general role for this protein in cell attachment.
    Title: The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.
  10. CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action
    Title: Identification of a role for CLASP2 in insulin action.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables dystroglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exit from mitosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule anchoring ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gastrulation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle targeting ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cortical microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CLIP-associating protein 2
Names
CLASP2alpha
CLASP2gamma
CLIP-associating protein CLASP2
cytoplasmic linker-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081960.1 → NP_001075429.1  CLIP-associating protein 2 isoform b

    See identical proteins and their annotated locations for NP_001075429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC107803, AK164326, BC117963
    Consensus CDS
    CCDS40787.1
    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    UniProtKB/TrEMBL
    Q08EB6
    Related
    ENSMUSP00000130201.3, ENSMUST00000166734.10
    Conserved Domains (2) summary
    pfam12348
    Location:100 → 311
    CLASP_N; CLASP N terminal
    sd00044
    Location:1057 → 1079
    HEAT; HEAT repeat [structural motif]

  2. NM_001114347.1 → NP_001107819.1  CLIP-associating protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC107803, AC167246
    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]

  3. NM_001286599.1 → NP_001273528.1  CLIP-associating protein 2 isoform d

    See identical proteins and their annotated locations for NP_001273528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, lacks a portion of the 3' coding region, and includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform d, which has a shorter and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AI529145, AK005146, AK034560
    Consensus CDS
    CCDS90675.1
    UniProtKB/TrEMBL
    Q8BSE7
    Related
    ENSMUSP00000150741.2, ENSMUST00000216817.2
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:81 → 197
    CLASP_N; CLASP N terminal

  4. NM_001286600.1 → NP_001273529.1  CLIP-associating protein 2 isoform e

    See identical proteins and their annotated locations for NP_001273529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform e, which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC107803, AK043551, AK148966
    Consensus CDS
    CCDS90676.1
    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    UniProtKB/TrEMBL
    Q08EB5
    Related
    ENSMUSP00000149670.2, ENSMUST00000214522.2
    Conserved Domains (2) summary
    pfam12348
    Location:100 → 311
    CLASP_N; CLASP N terminal
    sd00044
    Location:1074 → 1096
    HEAT; HEAT repeat [structural motif]

  5. NM_001286601.1 → NP_001273530.1  CLIP-associating protein 2 isoform f

    See identical proteins and their annotated locations for NP_001273530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC107803, AK043551, AK164326
    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    UniProtKB/TrEMBL
    A2RRR3
    Conserved Domains (2) summary
    pfam12348
    Location:2 → 113
    CLASP_N; CLASP N terminal
    sd00044
    Location:859 → 881
    HEAT; HEAT repeat [structural motif]

  6. NM_001286602.1 → NP_001273531.1  CLIP-associating protein 2 isoform g

    See identical proteins and their annotated locations for NP_001273531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC107803, AK043551, AK164326
    UniProtKB/TrEMBL
    B9EJA4, F7DCH5
    Related
    ENSMUSP00000128460.3, ENSMUST00000163895.3
    Conserved Domains (2) summary
    sd00044
    Location:1078 → 1100
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:99 → 311
    CLASP_N; CLASP N terminal

  7. NM_001286603.1 → NP_001273532.1  CLIP-associating protein 2 isoform h

    See identical proteins and their annotated locations for NP_001273532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform h) that is shorter at both the N- and C-termini, compared to isoform c.
    Source sequence(s)
    AK005146, BC030468, CJ052159
    UniProtKB/Swiss-Prot
    Q8BRT1
    Related
    ENSMUST00000213966.2

  8. NM_029633.2 → NP_083909.2  CLIP-associating protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC107803, AK164326, BC117963
    Consensus CDS
    CCDS52948.1
    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    UniProtKB/TrEMBL
    E9Q8N5
    Related
    ENSMUSP00000107469.3, ENSMUST00000111838.10
    Conserved Domains (2) summary
    pfam12348
    Location:100 → 311
    CLASP_N; CLASP N terminal
    sd00044
    Location:1056 → 1078
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    113567776..113748765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512384.5 → XP_006512447.1  CLIP-associating protein 2 isoform X1

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    pfam15782
    Location:641 → 813
    GREB1; Gene regulated by oestrogen in breast cancer

  2. XM_006512385.5 → XP_006512448.1  CLIP-associating protein 2 isoform X2

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    pfam15782
    Location:641 → 813
    GREB1; Gene regulated by oestrogen in breast cancer

  3. XM_006512387.5 → XP_006512450.1  CLIP-associating protein 2 isoform X4

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    pfam15782
    Location:641 → 813
    GREB1; Gene regulated by oestrogen in breast cancer

  4. XM_036155382.1 → XP_036011275.1  CLIP-associating protein 2 isoform X7

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam15402
    Location:687 → 809
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  5. XM_006512391.5 → XP_006512454.1  CLIP-associating protein 2 isoform X11

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (4) summary
    PHA03307
    Location:652 → 803
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  6. XM_006512392.5 → XP_006512455.1  CLIP-associating protein 2 isoform X12

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (4) summary
    PHA03307
    Location:652 → 803
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  7. XM_030244700.2 → XP_030100560.1  CLIP-associating protein 2 isoform X17

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (4) summary
    PHA03307
    Location:652 → 803
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  8. XM_036155381.1 → XP_036011274.1  CLIP-associating protein 2 isoform X6

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  9. XM_006512390.5 → XP_006512453.1  CLIP-associating protein 2 isoform X9

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  10. XM_030244699.2 → XP_030100559.1  CLIP-associating protein 2 isoform X10

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  11. XM_006512393.5 → XP_006512456.1  CLIP-associating protein 2 isoform X14

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  12. XM_036155385.1 → XP_036011278.1  CLIP-associating protein 2 isoform X16

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  13. XM_036155388.1 → XP_036011281.1  CLIP-associating protein 2 isoform X21

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  14. XM_030244701.2 → XP_030100561.1  CLIP-associating protein 2 isoform X24

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  15. XM_030244702.2 → XP_030100562.1  CLIP-associating protein 2 isoform X25

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  16. XM_006512386.5 → XP_006512449.1  CLIP-associating protein 2 isoform X3

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    pfam15402
    Location:681 → 803
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  17. XM_036155383.1 → XP_036011276.1  CLIP-associating protein 2 isoform X13

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  18. XM_036155389.1 → XP_036011282.1  CLIP-associating protein 2 isoform X23

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  19. XM_006512388.5 → XP_006512451.1  CLIP-associating protein 2 isoform X5

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    PHA03307
    Location:630 → 788
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  20. XM_036155384.1 → XP_036011277.1  CLIP-associating protein 2 isoform X15

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  21. XM_036155386.1 → XP_036011279.1  CLIP-associating protein 2 isoform X19

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  22. XM_036155387.1 → XP_036011280.1  CLIP-associating protein 2 isoform X20

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  23. XM_006512389.5 → XP_006512452.1  CLIP-associating protein 2 isoform X8

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal
    pfam15402
    Location:673 → 795
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

  24. XM_006512394.5 → XP_006512457.1  CLIP-associating protein 2 isoform X18

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  25. XM_006512397.5 → XP_006512460.1  CLIP-associating protein 2 isoform X22

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  26. XM_030244703.2 → XP_030100563.1  CLIP-associating protein 2 isoform X26

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  27. XM_030244704.2 → XP_030100564.1  CLIP-associating protein 2 isoform X27

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (3) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168 → 198
    HEAT; HEAT repeat
    pfam12348
    Location:327 → 538
    CLASP_N; CLASP N terminal

  28. XM_036155390.1 → XP_036011283.1  CLIP-associating protein 2 isoform X28

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:91 → 121
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:326 → 538
    CLASP_N; CLASP N terminal

  29. XM_030244705.2 → XP_030100565.1  CLIP-associating protein 2 isoform X29

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (4) summary
    sd00044
    Location:1224 → 1246
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:69 → 99
    HEAT; HEAT repeat
    pfam12348
    Location:228 → 439
    CLASP_N; CLASP N terminal
    pfam15782
    Location:542 → 714
    GREB1; Gene regulated by oestrogen in breast cancer

  30. XM_030244707.2 → XP_030100567.1  CLIP-associating protein 2 isoform X30

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1106 → 1128
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:109 → 321
    CLASP_N; CLASP N terminal

  31. XM_036155391.1 → XP_036011284.1  CLIP-associating protein 2 isoform X30

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1106 → 1128
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:109 → 321
    CLASP_N; CLASP N terminal

  32. XM_006512396.3 → XP_006512459.1  CLIP-associating protein 2 isoform X32

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:1090 → 1112
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:94 → 305
    CLASP_N; CLASP N terminal
    pfam15782
    Location:408 → 580
    GREB1; Gene regulated by oestrogen in breast cancer

  33. XM_036155394.1 → XP_036011287.1  CLIP-associating protein 2 isoform X35

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1072 → 1094
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  34. XM_036155399.1 → XP_036011292.1  CLIP-associating protein 2 isoform X40

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:1043 → 1065
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  35. XM_036155396.1 → XP_036011289.1  CLIP-associating protein 2 isoform X37

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1056 → 1078
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  36. XM_036155401.1 → XP_036011294.1  CLIP-associating protein 2 isoform X42

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:1035 → 1057
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  37. XM_036155392.1 → XP_036011285.1  CLIP-associating protein 2 isoform X33

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1076 → 1098
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  38. XM_036155395.1 → XP_036011288.1  CLIP-associating protein 2 isoform X36

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1058 → 1080
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  39. XM_036155398.1 → XP_036011291.1  CLIP-associating protein 2 isoform X39

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (2) summary
    sd00044
    Location:1050 → 1072
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  40. XM_036155402.1 → XP_036011295.1  CLIP-associating protein 2 isoform X43

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:1029 → 1051
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:93 → 305
    CLASP_N; CLASP N terminal

  41. XM_006512395.5 → XP_006512458.1  CLIP-associating protein 2 isoform X31

    UniProtKB/TrEMBL
    F7DCH5
    Conserved Domains (3) summary
    sd00044
    Location:1096 → 1118
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:100 → 311
    CLASP_N; CLASP N terminal
    pfam15782
    Location:414 → 586
    GREB1; Gene regulated by oestrogen in breast cancer

  42. XM_036155393.1 → XP_036011286.1  CLIP-associating protein 2 isoform X34

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (3) summary
    PHA03307
    Location:425 → 576
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:1075 → 1097
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:99 → 311
    CLASP_N; CLASP N terminal

  43. XM_036155397.1 → XP_036011290.1  CLIP-associating protein 2 isoform X38

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:1048 → 1070
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:99 → 311
    CLASP_N; CLASP N terminal

  44. XM_036155400.1 → XP_036011293.1  CLIP-associating protein 2 isoform X41

    UniProtKB/Swiss-Prot
    Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
    Conserved Domains (2) summary
    sd00044
    Location:1034 → 1056
    HEAT; HEAT repeat [structural motif]
    pfam12348
    Location:99 → 311
    CLASP_N; CLASP N terminal

RNA

  1. XR_379881.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRT1.1 GenPept UniProtKB/Swiss-Prot:Q8BRT1

Gene LinkOut

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