Ly6k lymphocyte antigen 6 family member K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly6kprovided by MGI
Official Full Name: lymphocyte antigen 6 family member Kprovided by MGI
Primary source: MGI:MGI:1923736
See related: Ensembl:ENSMUSG00000044678 AllianceGenome:MGI:1923736
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mLy-6K; 2410015A16Rik; 3110035B01Rik
Summary: Acts upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Located in acrosomal vesicle; cell surface; and plasma membrane. Is expressed in several structures, including central nervous system; reproductive system; retina; spleen; and stomach. Orthologous to human LY6K (lymphocyte antigen 6 family member K). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 130.0), thymus adult (RPKM 15.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74668723..74671817, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74796874..74799968, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrated that both TEX101 and Ly6k contribute mutually for their protein expression in the testicular germ cells, suggesting that the expression-balance of these two proteins is essential for fertile sperm formation.
Title: TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells.
LY6K is a newly identified factor involved in sperm fertilizing ability
Title: GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice.
This information is essential for the molecular classification of Ly6k, and may help uncover the detailed physiological role of Ly6k in gametogenesis, or cancer biology.
Title: Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells.
This study confirmed the biological interaction between TEX101 and Ly6k.
Title: TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis.
Expression profiling confirmed that mLy-6K is expressed by plasma cells but not B cells or tissues not containing plasma cells.
Title: Identification of Ly-6K as a novel marker for mouse plasma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lymphocyte antigen 6K

Names: ly-6K; lymphocyte antigen 6 complex, locus K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029627.2 → NP_083903.1 lymphocyte antigen 6K precursor

See identical proteins and their annotated locations for NP_083903.1

Status: PROVISIONAL

Source sequence(s)

AK010485

Consensus CDS

CCDS27532.1

UniProtKB/Swiss-Prot

Q9CWP4

Related

ENSMUSP00000052599.6, ENSMUST00000060301.6

Conserved Domains (1) summary

cd00117
Location:21 → 109

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...