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Glt8d1 glycosyltransferase 8 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 76485, updated on 5-Mar-2024

Summary

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Official Symbol
Glt8d1provided by MGI
Official Full Name
glycosyltransferase 8 domain containing 1provided by MGI
Primary source
MGI:MGI:1923735
See related
Ensembl:ENSMUSG00000021916 AllianceGenome:MGI:1923735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410004H05Rik; 5430414N14Rik
Summary
This gene encodes a member of the glycosyltransferase family. The encoded protein is a type II transmembrane protein containing a glycosyltransferase 8 domain in the lumenal (C-terminal) portion. The specific function of this protein has not been determined. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Sep 2009]
Expression
Broad expression in testis adult (RPKM 75.2), limb E14.5 (RPKM 20.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Glt8d1 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30723137..30733948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31001197..31012441)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene predicted gene, 24916 Neighboring gene guanine nucleotide binding protein nucleolar 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Yang CP, et al. Nat Commun, 2018 Feb 26. PMID 29483533, Free PMC Article
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycosyltransferase 8 domain-containing protein 1
NP_001159402.1
NP_001390227.1
NP_001390228.1
NP_001390229.1
NP_001390230.1
NP_001390234.1
NP_001390235.1
NP_001390237.1
NP_001390239.1
NP_001390265.1
NP_001390266.1
NP_001390267.1
NP_001390268.1
NP_001390269.1
NP_001390270.1
NP_001390271.1
NP_001390272.1
NP_001390273.1
NP_001390274.1
NP_083902.2
XP_036014787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165930.2 → NP_001159402.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001159402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154727
    Consensus CDS
    CCDS26904.1
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8
    Related
    ENSMUSP00000129323.2, ENSMUST00000168584.9
    Conserved Domains (1) summary
    cd06429
    Location:66 → 351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function

  2. NM_001403298.1 → NP_001390227.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  3. NM_001403299.1 → NP_001390228.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  4. NM_001403300.1 → NP_001390229.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  5. NM_001403301.1 → NP_001390230.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  6. NM_001403305.1 → NP_001390234.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  7. NM_001403306.1 → NP_001390235.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  8. NM_001403308.1 → NP_001390237.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  9. NM_001403310.1 → NP_001390239.1  glycosyltransferase 8 domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8

  10. NM_001403336.1 → NP_001390265.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154727

  11. NM_001403337.1 → NP_001390266.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154727
    Related
    ENSMUST00000228255.2

  12. NM_001403338.1 → NP_001390267.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154727

  13. NM_001403339.1 → NP_001390268.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154727

  14. NM_001403340.1 → NP_001390269.1  glycosyltransferase 8 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154727

  15. NM_001403341.1 → NP_001390270.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154727

  16. NM_001403342.1 → NP_001390271.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154727

  17. NM_001403343.1 → NP_001390272.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154727

  18. NM_001403344.1 → NP_001390273.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154727

  19. NM_001403345.1 → NP_001390274.1  glycosyltransferase 8 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154727

  20. NM_029626.3 → NP_083902.2  glycosyltransferase 8 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_083902.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154727
    Consensus CDS
    CCDS26904.1
    UniProtKB/Swiss-Prot
    Q3TV18, Q6NSU3, Q9CWT8
    Related
    ENSMUSP00000022476.8, ENSMUST00000022476.9
    Conserved Domains (1) summary
    cd06429
    Location:66 → 351
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30723137..30733948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158894.1 → XP_036014787.1  glycosyltransferase 8 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cd06429
    Location:316 → 601
    GT8_like_1; GT8_like_1 represents a subfamily of GT8 with unknown function
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSU3.1 GenPept UniProtKB/Swiss-Prot:Q6NSU3

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