Kndc1 kinase non-catalytic C-lobe domain (KIND) containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kndc1provided by MGI
Official Full Name: kinase non-catalytic C-lobe domain (KIND) containing 1provided by MGI
Primary source: MGI:MGI:1923734
See related: Ensembl:ENSMUSG00000066129 AllianceGenome:MGI:1923734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VKIND; v-KIND; very-kind; 2410012C07Rik; B830014K08Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cerebellar granule cell differentiation; positive regulation of protein phosphorylation; and regulation of dendrite morphogenesis. Located in dendrite and neuronal cell body. Part of guanyl-nucleotide exchange factor complex. Is expressed in lung; nervous system; neural retina; ovary; and thymus. Orthologous to human KNDC1 (kinase non-catalytic C-lobe domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 28.3), cortex adult (RPKM 9.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 84.89 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (139474612..139521453)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (139894696..139941540)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our results suggest that v-KIND is required for compact dendritic growth and proper excitatory synaptic connections in cerebellar granule cells, which are necessary for normal motor coordination and balance.
Title: The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination.
results demonstrate the structural and functional determinant underlying the v-KIND-MAP2 interaction that controls dendrite arborization patterns
Title: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth--structure and function of the second kinase noncatalytic C-lobe domain.
v-KIND mediates a signaling pathway that links Ras and MAP2 to control dendrite growth
Title: Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.
During mouse embryogenesis the VKIND gene was specifically expressed in the developing nervous system.
Title: Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kndc1 (e-PCR), detects polymorphism
- UniSTS:531456

AI144728 (e-PCR)
- UniSTS:261213

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of dendrite morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of guanyl-nucleotide exchange factor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinase non-catalytic C-lobe domain-containing protein 1

Names: KIND domain-containing protein 1; protein very KIND; ras-GEF domain-containing family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177261.4 → NP_796235.4 kinase non-catalytic C-lobe domain-containing protein 1

See identical proteins and their annotated locations for NP_796235.4

Status: VALIDATED

Source sequence(s)

AK046817, AK147335, BE994731

UniProtKB/Swiss-Prot

Q0KK50, Q0KK55, Q3TF27, Q3UGX9, Q3UGZ3, Q3UHK4, Q7TNH0, Q8BTH5, Q8BXJ3

UniProtKB/TrEMBL

B2RX11

Related

ENSMUSP00000050586.12, ENSMUST00000053445.18

Conserved Domains (3) summary

cd06224
Location:1247 → 1362

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

pfam00617
Location:1468 → 1612

RasGEF; RasGEF domain

cl21453
Location:37 → 216

PKc_like; Protein Kinases, catalytic domain