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Haus8 4HAUS augmin-like complex, subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 76478, updated on 11-Apr-2024

Summary

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Official Symbol
Haus8provided by MGI
Official Full Name
4HAUS augmin-like complex, subunit 8provided by MGI
Primary source
MGI:MGI:1923728
See related
Ensembl:ENSMUSG00000035439 AllianceGenome:MGI:1923728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hice1; 2410004L22Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in centrosome; cytoplasm; and nuclear microtubule. Orthologous to human HAUS8 (HAUS augmin like complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 13.3), liver E14.5 (RPKM 11.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71703241..71725234, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71250597..71272627, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29701 Neighboring gene adenine phosphoribosyl transferase, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1105 Neighboring gene myosin IXb Neighboring gene STARR-positive B cell enhancer ABC_E6650 Neighboring gene unconventional SNARE in the ER 1 homolog (S. cerevisiae) Neighboring gene occludin/ELL domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. Kole C, et al. PLoS One, 2016. PMID 26985665, Free PMC Article
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HAUS augmin-like complex subunit 8
Names
HEC1/NDC80 interacting, centrosome associated 1
HEC1/NDC80-interacting centrosome-associated protein 1
sarcoma antigen NY-SAR-48 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163042.1 → NP_001156514.1  HAUS augmin-like complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_001156514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI837612, BQ177845, CX220280, DV651534
    Consensus CDS
    CCDS52579.1
    UniProtKB/Swiss-Prot
    Q99L00, Q9CWT4
    Related
    ENSMUSP00000040802.7, ENSMUST00000035960.13

  2. NM_001363402.1 → NP_001350331.1  HAUS augmin-like complex subunit 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157609, CX226399

  3. NM_001363403.1 → NP_001350332.1  HAUS augmin-like complex subunit 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157609

  4. NM_001363404.1 → NP_001350333.1  HAUS augmin-like complex subunit 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157609, AK161850

  5. NM_001363405.1 → NP_001350334.1  HAUS augmin-like complex subunit 8 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 6.
    Source sequence(s)
    AC157609

  6. NM_001363406.1 → NP_001350335.1  HAUS augmin-like complex subunit 8 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 6.
    Source sequence(s)
    AC157609, FO719432

  7. NM_029621.3 → NP_083897.2  HAUS augmin-like complex subunit 8 isoform 2

    See identical proteins and their annotated locations for NP_083897.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
    Source sequence(s)
    AI837612, AK010398, BQ177845, CX220280
    Consensus CDS
    CCDS22389.1
    UniProtKB/Swiss-Prot
    Q99L00
    Related
    ENSMUSP00000105698.3, ENSMUST00000110071.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71703241..71725234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509779.5 → XP_006509842.1  HAUS augmin-like complex subunit 8 isoform X1

  2. XM_030243836.2 → XP_030099696.1  HAUS augmin-like complex subunit 8 isoform X3

  3. XM_036154365.1 → XP_036010258.1  HAUS augmin-like complex subunit 8 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L00.2 GenPept UniProtKB/Swiss-Prot:Q99L00

Gene LinkOut

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