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Msrb2 methionine sulfoxide reductase B2 [ Mus musculus (house mouse) ]

Gene ID: 76467, updated on 5-Mar-2024

Summary

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Official Symbol
Msrb2provided by MGI
Official Full Name
methionine sulfoxide reductase B2provided by MGI
Primary source
MGI:MGI:1923717
See related
Ensembl:ENSMUSG00000023094 AllianceGenome:MGI:1923717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrsb; Msrb; Pilb; 2310050L06Rik
Summary
Enables actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Involved in actin filament polymerization. Acts upstream of or within protein repair. Located in mitochondrion. Is expressed in several structures, including brown fat; heart; inner ear; skeletal muscle; and testis. Orthologous to human MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.8), kidney adult (RPKM 6.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 13.26 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (19376247..19399787)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (19371436..19394976)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E5893 Neighboring gene RIKEN cDNA 4930447M23 gene Neighboring gene STARR-seq mESC enhancer starr_03820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:19310470-19310705 Neighboring gene STARR-seq mESC enhancer starr_03823 Neighboring gene STARR-seq mESC enhancer starr_03825 Neighboring gene STARR-positive B cell enhancer ABC_E11703 Neighboring gene predicted gene, 33940 Neighboring gene predicted gene 13344 Neighboring gene pancreas specific transcription factor 1a, opposite strand Neighboring gene pancreas specific transcription factor, 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2. Aachmann FL, et al. Proteins, 2011 Nov. PMID 21989933, Free PMC Article
  2. Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology. Xiang XJ, et al. Exp Neurol, 2019 Aug. PMID 31078523
  3. Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. Le DT, et al. Biochemistry, 2008 Jun 24. PMID 18505275, Free PMC Article
  4. Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. Kim HY, et al. PLoS Biol, 2005 Dec. PMID 16262444, Free PMC Article
  5. Mitochondrial MsrB2 serves as a switch and transducer for mitophagy. Lee SH, et al. EMBO Mol Med, 2019 Aug. PMID 31282614, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy.
    Title: Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
  2. the role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible.
    Title: Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.
  3. Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
    Title: Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.
  4. overall structure is composed of two beta-sheets consisting of eight antiparallel beta-strands and three N-terminal alpha-helices and is more similar to those of bacterial MsrBs than to that of mammalian MsrB1
    Title: Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.
  5. Studies show all Met sulfoxide residues in an MRP can be reduced by MsrA and MsrB.
    Title: Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.
  6. MsrA and MsrB2, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies.
    Title: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
  7. Results show that mammalian MsrB and MsrA proteins perform crucial functions in protection against oxidative stress in lower eukaryotic yeast cells.
    Title: Expression, subcellular localization, and antioxidant role of mammalian methionine sulfoxide reductases in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methionine-R-sulfoxide reductase B2, mitochondrial
Names
pilin-like transcription factor
NP_083895.1
XP_006497626.1
XP_017174809.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029619.2 → NP_083895.1  methionine-R-sulfoxide reductase B2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083895.1

    Status: PROVISIONAL

    Source sequence(s)
    BC021619
    Consensus CDS
    CCDS15714.1
    UniProtKB/Swiss-Prot
    Q78J03
    Related
    ENSMUSP00000023856.9, ENSMUST00000023856.9
    Conserved Domains (1) summary
    PRK00222
    Location:43 → 172
    PRK00222; methionine sulfoxide reductase B; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    19376247..19399787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319320.2 → XP_017174809.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl15841
    Location:124 → 150
    SelR; SelR domain

  2. XM_006497563.3 → XP_006497626.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam01641
    Location:18 → 144
    SelR; SelR domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78J03.1 GenPept UniProtKB/Swiss-Prot:Q78J03

Gene LinkOut

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