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Car12 carbonic anhydrase 12 [ Mus musculus (house mouse) ]

Gene ID: 76459, updated on 21-Apr-2024

Summary

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Official Symbol
Car12provided by MGI
Official Full Name
carbonic anhydrase 12provided by MGI
Primary source
MGI:MGI:1923709
See related
Ensembl:ENSMUSG00000032373 AllianceGenome:MGI:1923709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca12; CA-XII; 2310047E01Rik
Summary
This gene encodes a membrane-bound member of the alpha carbonic anhydrase family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate. These proteins participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in kidney adult (RPKM 57.2), limb E14.5 (RPKM 7.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 36.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66619026..66674127)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66712296..66766845)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:66213808-66214109 Neighboring gene predicted gene, 50499 Neighboring gene predicted gene, 23428 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66312941-66313241 Neighboring gene STARR-positive B cell enhancer ABC_E3841 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66351571-66351871 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66440763-66441064 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66444915-66445215 Neighboring gene STARR-positive B cell enhancer ABC_E2900 Neighboring gene STARR-seq mESC enhancer starr_24480 Neighboring gene STARR-positive B cell enhancer ABC_E11413 Neighboring gene STARR-positive B cell enhancer ABC_E8296 Neighboring gene aph1 homolog B, gamma secretase subunit Neighboring gene cDNA sequence BC050972

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis. Bouchareb R, et al. J Mol Cell Cardiol, 2015 May. PMID 25771146
  2. Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs. Hynninen P, et al. Reprod Biol Endocrinol, 2004 Oct 17. PMID 15488153, Free PMC Article
  3. Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues. Halmi P, et al. Anat Rec A Discov Mol Cell Evol Biol, 2004 Mar. PMID 14983512
  4. Expression of carbonic anhydrases IX and XII during mouse embryonic development. Kallio H, et al. BMC Dev Biol, 2006 May 23. PMID 16719910, Free PMC Article
  5. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. Geurts AM, et al. BMC Biotechnol, 2006 Jun 26. PMID 16800892, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P2Y2R-mediated expression of CAXII by VICs acidifies the extracellular space and promotes the regression of CAVS.
    Title: Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis.
  2. During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes.
    Title: A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
  3. Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland.
    Title: Carbonic anhydrases in the mouse harderian gland.
  4. High expression in the kidney and colon suggests a role for carbonic anhydrase XII in the maintenance of body ion and pH homeostasis in the mouse.
    Title: Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues.
  5. CA12 may regulate ion and pH homeostasis within the developing embryo.
    Title: Expression of carbonic anhydrases IX and XII during mouse embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbon dioxide transport IC
Inferred by Curator
more info
 PubMed 
involved_in chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of pH IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbonic anhydrase 12
Names
CA XII
carbonate dehydratase XII
carbonic anhydrase XII
NP_001293077.1
NP_848483.3
XP_006511611.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306148.1 → NP_001293077.1  carbonic anhydrase 12 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001293077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC134429, AI414285, AK009873, AK052639, BU700194, BX513273, BY236613, CX240181
    Consensus CDS
    CCDS81026.1
    UniProtKB/Swiss-Prot
    Q8BKG6, Q8CI85
    UniProtKB/TrEMBL
    Q8K2J1
    Related
    ENSMUSP00000082541.6, ENSMUST00000085420.12
    Conserved Domains (1) summary
    cl00012
    Location:39 → 290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. NM_178396.5 → NP_848483.3  carbonic anhydrase 12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848483.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134429, AI414285, AK009873, AK052639, BU700194, BX513273, BY236613, CX240181
    Consensus CDS
    CCDS23306.1
    UniProtKB/Swiss-Prot
    Q8BKG6, Q8CI85
    UniProtKB/TrEMBL
    A0A0R4J0W4, Q3TC80
    Related
    ENSMUSP00000071786.7, ENSMUST00000071889.13
    Conserved Domains (1) summary
    cl00012
    Location:39 → 290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66619026..66674127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511548.5 → XP_006511611.1  carbonic anhydrase 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8BKG6, Q8CI85
    UniProtKB/TrEMBL
    Q3TC80
    Conserved Domains (1) summary
    cl00012
    Location:39 → 290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI85.1 GenPept UniProtKB/Swiss-Prot:Q8CI85

Gene LinkOut

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