U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppp1r18 protein phosphatase 1, regulatory subunit 18 [ Mus musculus (house mouse) ]

Gene ID: 76448, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ppp1r18provided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 18provided by MGI
Primary source
MGI:MGI:1923698
See related
Ensembl:ENSMUSG00000034595 AllianceGenome:MGI:1923698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310014H01Rik
Summary
Predicted to enable actin binding activity and phosphatase binding activity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in nervous system. Orthologous to human PPP1R18 (protein phosphatase 1 regulatory subunit 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 30.8), thymus adult (RPKM 21.9) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 B1; 17 18.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36176483..36186488)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35865593..35875596)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42479 Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene nurim (nuclear envelope membrane protein) Neighboring gene STARR-seq mESC enhancer starr_42480 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36016615-36016802 Neighboring gene DEAH-box helicase 16 Neighboring gene RIKEN cDNA 2310061I04 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs. Lee HS, et al. J Exp Med, 2022 Aug 1. PMID 35766979, Free PMC Article
  2. The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts. Matsubara T, et al. Mol Cell Biol, 2018 Feb 15. PMID 29158294, Free PMC Article
  3. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
  4. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
  5. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs.
    Title: Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phostensin
Names
protein phosphatase 1 F-actin cytoskeleton-targeting subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146710.1 → NP_001140182.1  phostensin isoform 1

    See identical proteins and their annotated locations for NP_001140182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK009340, AK149943
    Consensus CDS
    CCDS50094.1
    UniProtKB/Swiss-Prot
    B8JJ63, B8JJ64, Q3UDS6, Q8BQ30, Q8CEY9, Q8R3D8
    UniProtKB/TrEMBL
    B2RWV7, B7ZND7
    Related
    ENSMUSP00000120343.2, ENSMUST00000122899.8
    Conserved Domains (2) summary
    pfam13914
    Location:425 → 540
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:28 → 117
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

  2. NM_001146711.1 → NP_001140183.1  phostensin isoform 1

    See identical proteins and their annotated locations for NP_001140183.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    CR974451
    Consensus CDS
    CCDS50094.1
    UniProtKB/Swiss-Prot
    B8JJ63, B8JJ64, Q3UDS6, Q8BQ30, Q8CEY9, Q8R3D8
    UniProtKB/TrEMBL
    B2RWV7, B7ZND7
    Related
    ENSMUSP00000116100.2, ENSMUST00000144382.8
    Conserved Domains (2) summary
    pfam13914
    Location:425 → 540
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:28 → 117
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

  3. NM_001378889.1 → NP_001365818.1  phostensin isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974451
    UniProtKB/TrEMBL
    B2RWV7, B7ZND7
    Conserved Domains (2) summary
    pfam13914
    Location:468 → 583
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:71 → 160
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

  4. NM_175242.1 → NP_780451.1  phostensin isoform 1

    See identical proteins and their annotated locations for NP_780451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK051656, BY198945, CR974451
    Consensus CDS
    CCDS50094.1
    UniProtKB/Swiss-Prot
    B8JJ63, B8JJ64, Q3UDS6, Q8BQ30, Q8CEY9, Q8R3D8
    UniProtKB/TrEMBL
    B2RWV7, B7ZND7
    Related
    ENSMUSP00000141094.2, ENSMUST00000187690.7
    Conserved Domains (2) summary
    pfam13914
    Location:425 → 540
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:28 → 117
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36176483..36186488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525092.5 → XP_006525155.2  phostensin isoform X1

    UniProtKB/TrEMBL
    B2RWV7, B7ZND7
    Related
    ENSMUSP00000115753.2, ENSMUST00000127442.8
    Conserved Domains (2) summary
    pfam13914
    Location:425 → 540
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:28 → 117
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQ30.1 GenPept UniProtKB/Swiss-Prot:Q8BQ30

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous