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Abcc3 ATP-binding cassette, sub-family C member 3 [ Mus musculus (house mouse) ]

Gene ID: 76408, updated on 11-Apr-2024

Summary

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Official Symbol
Abcc3provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 3provided by MGI
Primary source
MGI:MGI:1923658
See related
Ensembl:ENSMUSG00000020865 AllianceGenome:MGI:1923658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLP2; MRP3; ABC31; MOAT-D; 1700019L09Rik
Summary
Predicted to enable ABC-type transporter activity; glucuronoside transmembrane transporter activity; and icosanoid transmembrane transporter activity. Predicted to be involved in anion transport and xenobiotic transmembrane transport. Predicted to act upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Is integral component of plasma membrane. Is expressed in alimentary system; liver; and small intestine. Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 63.1), colon adult (RPKM 54.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 58.9 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94234121..94283843, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94343295..94393017, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene LUC7-like 3 (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E5270 Neighboring gene STARR-positive B cell enhancer ABC_E7046 Neighboring gene ankyrin repeat domain 40 Neighboring gene predicted gene, 51871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94235659-94235882 Neighboring gene STARR-seq mESC enhancer starr_30466 Neighboring gene STARR-seq mESC enhancer starr_30467 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1G subunit Neighboring gene STARR-seq mESC enhancer starr_30468 Neighboring gene predicted gene, 51872 Neighboring gene STARR-positive B cell enhancer ABC_E10707 Neighboring gene spermatogenesis associated 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation. Tai T, et al. J Cardiovasc Pharmacol, 2016 Dec. PMID 27525577
  2. Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. Wiel C, et al. Oncogene, 2016 Mar 24. PMID 26073088
  3. Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice. Fernández-Barrena MG, et al. J Hepatol, 2012 Feb. PMID 21756856
  4. Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine. Kitamura Y, et al. J Pharmacol Exp Ther, 2010 Feb. PMID 19889793
  5. Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Manautou JE, et al. Hepatology, 2005 Nov. PMID 16250050

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abbcc3 knock-out mice have enhanced platelet response to clopidogrel due to increased formation of clopidogral active metabolite.
    Title: Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation.
  2. data show that this transporter activity is involved in ABCC3-induced senescence, demonstrating that this protein has a complex role in cancer, since its loss of function may promote escape from OIS and tumor formation
    Title: Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape.
  3. Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively.
    Title: Oral availability of cefadroxil depends on ABCC3 and ABCC4.
  4. role of the bile acid membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut, in the hepatic growth response elicited by bile acids and in liver regeneration after partial hepatectomy
    Title: Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice.
  5. Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX.
    Title: Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models.
  6. InsP(3)R2-mediated Ca(2+) signals enhance organic anion secretion into bile by targeting Mrp2 to the canalicular membrane.
    Title: Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.
  7. Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX.
    Title: Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.
  8. These results suggest that Mrp3 plays major roles in the efflux transport of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s)
    Title: Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine.
  9. Complex pharmacokinetic behavior of ezetimibe depends on intestinal abcc2, abcc3, and abcg2.
    Title: Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.
  10. Report Role of hepatic Mrp3 transporter in prevention of bile acid toxicity after partial hepatectomy in mice.
    Title: Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type bile acid transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type glutathione S-conjugate transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables icosanoid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within canalicular bile acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 3
Names
ATP-binding cassette protein C3
ATP-binding cassette transporter
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
canalicular multispecific organic anion transporter 2
multidrug resistance-associated protein 3
transporter
NP_001350116.1
NP_001350118.1
NP_083876.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363187.1 → NP_001350116.1  ATP-binding cassette sub-family C member 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645965
    Consensus CDS
    CCDS88225.1
    UniProtKB/Swiss-Prot
    B2RX12, J3QML2, Q3U1W8, Q56PH0, Q59DK9, Q59DL0, Q5SUF4, Q80ZK8
    Related
    ENSMUSP00000136343.2, ENSMUST00000178136.8
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1522
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  2. NM_001363189.1 → NP_001350118.1  ATP-binding cassette sub-family C member 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645965
    Conserved Domains (1) summary
    cl26602
    Location:7 → 1497
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

  3. NM_029600.4 → NP_083876.3  ATP-binding cassette sub-family C member 3 isoform 2

    See identical proteins and their annotated locations for NP_083876.3

    Status: VALIDATED

    Source sequence(s)
    AK149551, AL645965
    Consensus CDS
    CCDS25254.1
    UniProtKB/TrEMBL
    A0A0R4J015
    Related
    ENSMUSP00000021231.8, ENSMUST00000021231.8
    Conserved Domains (5) summary
    TIGR00957
    Location:7 → 1521
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1282 → 1502
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:626 → 827
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:976 → 1235
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:316 → 577
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94234121..94283843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_879762.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RX12.2 GenPept UniProtKB/Swiss-Prot:B2RX12

Gene LinkOut

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