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ZNF85 zinc finger protein 85 [ Homo sapiens (human) ]

Gene ID: 7639, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF85provided by HGNC
Official Full Name
zinc finger protein 85provided by HGNC
Primary source
HGNC:HGNC:13160
See related
Ensembl:ENSG00000105750 MIM:603899; AllianceGenome:HGNC:13160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPF4; HTF1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.6) and 21 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (20923251..20950697)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21061743..21089195)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21106057..21133503)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene proline rich 21 pseudogene Neighboring gene proline rich 21 pseudogene Neighboring gene keratin 18 pseudogene 40 Neighboring gene uncharacterized LOC112268247

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein a Potential Basis for Autoimmune Responses in Vaccinated and Naturally Infected Patients? Carnevale S, et al. Semin Thromb Hemost, 2023 Feb. PMID 35021248
  2. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. Poncelet DA, et al. DNA Cell Biol, 1998 Nov. PMID 9839802
  3. Enhanced expression in seminoma of human zinc finger genes located on chromosome 19. Ogawa T, et al. Cancer Genet Cytogenet, 1998 Jan 1. PMID 9406578
  4. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
  5. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1991 May 1. PMID 2023909, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein a Potential Basis for Autoimmune Responses in Vaccinated and Naturally Infected Patients?
    Title: Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein a Potential Basis for Autoimmune Responses in Vaccinated and Naturally Infected Patients?
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC78566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 85
Names
zinc finger protein 85 (HPF4, HTF1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256171.2 → NP_001243100.1  zinc finger protein 85 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC008739, BC036394, BC047646, BP199573, DC358791
    UniProtKB/TrEMBL
    Q49A12
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:174 → 588
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:514 → 534
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:582 → 606
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001256172.2 → NP_001243101.1  zinc finger protein 85 isoform b

    See identical proteins and their annotated locations for NP_001243101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 3, resulting in an isoform (b) that has a distinct C-terminus and is significantly shorter than isoform c.
    Source sequence(s)
    AC008739, BC068066, BM755583, BP199573
    Consensus CDS
    CCDS58657.1
    UniProtKB/Swiss-Prot
    Q03923
    Related
    ENSP00000300540.2, ENST00000300540.7
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    cl19880
    Location:50 → 68
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  3. NM_001256173.2 → NP_001243102.1  zinc finger protein 85 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' coding region, uses a downstream start codon, and lacks an in-frame exon in the 3' coding region, compared to variant 3. The encoded isoform (d) is shorter at the N-terminus, compared to isoform c.
    Source sequence(s)
    AC008739, BC036394, BC047646, BP199573, DB119881
    UniProtKB/TrEMBL
    Q49A12
    Conserved Domains (3) summary
    COG5048
    Location:80 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:488 → 512
    zf-H2C2_2; Zinc-finger double domain

  4. NM_003429.5 → NP_003420.2  zinc finger protein 85 isoform a

    See identical proteins and their annotated locations for NP_003420.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3, resulting in an isoform (a) that is shorter than isoform c.
    Source sequence(s)
    AC008739, BC047646, BP199573, DB524732, U35376
    Consensus CDS
    CCDS32977.1
    UniProtKB/Swiss-Prot
    B9ZVP4, Q03923, Q6NVI0
    Related
    ENSP00000329793.7, ENST00000328178.13
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:144 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:552 → 576
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_045830.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate exon structure at its 5' and 3' regions, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported start codon, as used in variant 3, results in only a 10 aa ORF, and the transcript does not contain any other supported ORF that is likely to be translated.
    Source sequence(s)
    AC008739, BC008688, BC068066, BP199573
    Related
    ENST00000596476.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    20923251..20950697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439353.1 → XP_047295309.1  zinc finger protein 85 isoform X2

  2. XM_011528263.3 → XP_011526565.1  zinc finger protein 85 isoform X1

    See identical proteins and their annotated locations for XP_011526565.1

    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:189 → 603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:597 → 621
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047439355.1 → XP_047295311.1  zinc finger protein 85 isoform X5

  4. XM_047439357.1 → XP_047295313.1  zinc finger protein 85 isoform X5

  5. XM_047439354.1 → XP_047295310.1  zinc finger protein 85 isoform X3

  6. XM_047439358.1 → XP_047295314.1  zinc finger protein 85 isoform X5

  7. XM_011528264.1 → XP_011526566.1  zinc finger protein 85 isoform X4

    See identical proteins and their annotated locations for XP_011526566.1

    UniProtKB/TrEMBL
    Q49A12
    Related
    ENST00000601023.2
    Conserved Domains (2) summary
    COG5048
    Location:169 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:425 → 445
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_047439356.1 → XP_047295312.1  zinc finger protein 85 isoform X5

  9. XM_047439359.1 → XP_047295315.1  zinc finger protein 85 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315962.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    266527..293973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329586.1 → XP_054185561.1  zinc finger protein 85 isoform X2

  2. XM_054329585.1 → XP_054185560.1  zinc finger protein 85 isoform X1

  3. XM_054329589.1 → XP_054185564.1  zinc finger protein 85 isoform X5

  4. XM_054329591.1 → XP_054185566.1  zinc finger protein 85 isoform X5

  5. XM_054329587.1 → XP_054185562.1  zinc finger protein 85 isoform X3

  6. XM_054329592.1 → XP_054185567.1  zinc finger protein 85 isoform X5

  7. XM_054329588.1 → XP_054185563.1  zinc finger protein 85 isoform X4

    UniProtKB/TrEMBL
    Q49A12

  8. XM_054329590.1 → XP_054185565.1  zinc finger protein 85 isoform X5

  9. XM_054329593.1 → XP_054185568.1  zinc finger protein 85 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    21061743..21089195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321988.1 → XP_054177963.1  zinc finger protein 85 isoform X2

  2. XM_054321987.1 → XP_054177962.1  zinc finger protein 85 isoform X1

  3. XM_054321991.1 → XP_054177966.1  zinc finger protein 85 isoform X5

  4. XM_054321993.1 → XP_054177968.1  zinc finger protein 85 isoform X5

  5. XM_054321989.1 → XP_054177964.1  zinc finger protein 85 isoform X3

  6. XM_054321994.1 → XP_054177969.1  zinc finger protein 85 isoform X5

  7. XM_054321990.1 → XP_054177965.1  zinc finger protein 85 isoform X4

    UniProtKB/TrEMBL
    Q49A12

  8. XM_054321992.1 → XP_054177967.1  zinc finger protein 85 isoform X5

  9. XM_054321995.1 → XP_054177970.1  zinc finger protein 85 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03923.3 GenPept UniProtKB/Swiss-Prot:Q03923

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