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Det1 DET1 partner of COP1 E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 76375, updated on 11-Apr-2024

Summary

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Official Symbol
Det1provided by MGI
Official Full Name
DET1 partner of COP1 E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:1923625
See related
Ensembl:ENSMUSG00000030610 AllianceGenome:MGI:1923625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610034H20Rik
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DET1 (DET1 partner of COP1 E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 6.1), ovary adult (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 44.81 cM; 7 D2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78471293..78497272, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (78821545..78847524, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:85927896-85928197 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene STARR-seq mESC enhancer starr_19254 Neighboring gene STARR-seq mESC enhancer starr_19255 Neighboring gene predicted gene, 57212 Neighboring gene STARR-seq mESC enhancer starr_19256 Neighboring gene microRNA 7-2 Neighboring gene predicted gene, 39039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of Arabidopsis ABF1/3/4 during det1 germination in salt and osmotic stress conditions. Fernando VCD, et al. Plant Mol Biol, 2018 May. PMID 29680877
  2. Transcription factor Etv5 is essential for the maintenance of alveolar type II cells. Zhang Z, et al. Proc Natl Acad Sci U S A, 2017 Apr 11. PMID 28351980, Free PMC Article
  3. Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Newton K, et al. Proc Natl Acad Sci U S A, 2018 Oct 30. PMID 30322923, Free PMC Article
  4. Cryptochromes-Mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Rizzini L, et al. Curr Biol, 2019 Jun 17. PMID 31155351, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DET1 homolog
Names
de-etiolated homolog 1
de-etiolated-1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419047.1 → NP_001405976.1  DET1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  2. NM_001419048.1 → NP_001405977.1  DET1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  3. NM_001419049.1 → NP_001405978.1  DET1 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  4. NM_001419050.1 → NP_001405979.1  DET1 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  5. NM_029585.4 → NP_083861.1  DET1 homolog isoform 1

    See identical proteins and their annotated locations for NP_083861.1

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556
    Consensus CDS
    CCDS21375.1
    UniProtKB/Swiss-Prot
    Q9D0A0
    Related
    ENSMUSP00000032839.7, ENSMUST00000032839.13
    Conserved Domains (1) summary
    pfam09737
    Location:142 → 546
    Det1; De-etiolated protein 1 Det1

RNA

  1. NR_185006.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  2. NR_185007.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  3. NR_185008.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  4. NR_185009.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  5. NR_185010.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  6. NR_185011.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

  7. NR_185012.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138376, AC156556

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    78471293..78497272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243076.2 → XP_030098936.1  DET1 homolog isoform X3

    Conserved Domains (1) summary
    pfam09737
    Location:142 → 488
    Det1; De-etiolated protein 1 Det1

  2. XM_006541269.4 → XP_006541332.1  DET1 homolog isoform X4

    Conserved Domains (1) summary
    pfam09737
    Location:142 → 487
    Det1; De-etiolated protein 1 Det1

RNA

  1. XR_004934203.1 RNA Sequence

  2. XR_004934200.1 RNA Sequence

  3. XR_004934202.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0A0.2 GenPept UniProtKB/Swiss-Prot:Q9D0A0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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