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ZNF84 zinc finger protein 84 [ Homo sapiens (human) ]

Gene ID: 7637, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF84provided by HGNC
Official Full Name
zinc finger protein 84provided by HGNC
Primary source
HGNC:HGNC:13159
See related
Ensembl:ENSG00000198040 MIM:618554; AllianceGenome:HGNC:13159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPF2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.4), endometrium (RPKM 6.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
12q24.33; map from Rosati ref via FISH [AFS]
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133037509..133063299)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133094846..133120602)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133614095..133639885)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene zinc finger protein 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene ZNF84 divergent transcript Neighboring gene PTP4A1 pseudogene 2 Neighboring gene MPRA-validated peak2056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7399 Neighboring gene zinc finger protein 140 Neighboring gene zinc finger protein 891 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26217 Neighboring gene ribosomal protein L23a pseudogene 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased ZNF84 expression in cervical cancer. Li P, et al. Arch Gynecol Obstet, 2018 Jun. PMID 29610946
  2. Assignment to chromosome 12q24.33, gene organization and splicing of the human KRAB/FPB containing zinc finger gene ZNF84. Rosati M, et al. Cytogenet Cell Genet, 2001. PMID 11856868
  3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. Rosati M, et al. Nucleic Acids Res, 1991 Oct 25. PMID 1945843, Free PMC Article
  4. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF84 expression was increased in CC [cervical cancer ] tissues and associated with tumor size. ZNF84 promoted cell proliferation which might involve Akt signal.
    Title: Increased ZNF84 expression in cervical cancer.
  2. FISH assignment to chromosome 12q24.33; gene organization and splicing
    Title: Assignment to chromosome 12q24.33, gene organization and splicing of the human KRAB/FPB containing zinc finger gene ZNF84.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 84
Names
zinc finger protein HPF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127372.3 → NP_001120844.1  zinc finger protein 84

    See identical proteins and their annotated locations for NP_001120844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC073911
    Consensus CDS
    CCDS31940.1
    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001289971.2 → NP_001276900.1  zinc finger protein 84

    See identical proteins and their annotated locations for NP_001276900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC073911
    Consensus CDS
    CCDS31940.1
    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Related
    ENSP00000445549.1, ENST00000539354.6
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001289972.2 → NP_001276901.1  zinc finger protein 84

    See identical proteins and their annotated locations for NP_001276901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC073911
    Consensus CDS
    CCDS31940.1
    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Related
    ENSP00000331465.7, ENST00000327668.11
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

  4. NM_003428.6 → NP_003419.3  zinc finger protein 84

    See identical proteins and their annotated locations for NP_003419.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC073911
    Consensus CDS
    CCDS31940.1
    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Related
    ENSP00000376133.2, ENST00000392319.6
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    133037509..133063299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429505.1 → XP_047285461.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  2. XM_047429511.1 → XP_047285467.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  3. XM_047429507.1 → XP_047285463.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  4. XM_047429504.1 → XP_047285460.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  5. XM_011534832.2 → XP_011533134.1  zinc finger protein 84 isoform X1

    See identical proteins and their annotated locations for XP_011533134.1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

  6. XM_047429506.1 → XP_047285462.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  7. XM_005266186.2 → XP_005266243.1  zinc finger protein 84 isoform X1

    See identical proteins and their annotated locations for XP_005266243.1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

  8. XM_005266185.2 → XP_005266242.1  zinc finger protein 84 isoform X1

    See identical proteins and their annotated locations for XP_005266242.1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Related
    ENSP00000437949.1, ENST00000543758.5
    Conserved Domains (4) summary
    smart00349
    Location:9 → 68
    KRAB; krueppel associated box
    COG5048
    Location:317 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 302
    zf-H2C2_2; Zinc-finger double domain

  9. XM_047429508.1 → XP_047285464.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  10. XM_047429510.1 → XP_047285466.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  11. XM_047429509.1 → XP_047285465.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    133094846..133120602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373140.1 → XP_054229115.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  2. XM_054373138.1 → XP_054229113.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  3. XM_054373136.1 → XP_054229111.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  4. XM_054373139.1 → XP_054229114.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  5. XM_054373137.1 → XP_054229112.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  6. XM_054373135.1 → XP_054229110.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  7. XM_054373143.1 → XP_054229118.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  8. XM_054373142.1 → XP_054229117.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

  9. XM_054373141.1 → XP_054229116.1  zinc finger protein 84 isoform X1

    UniProtKB/Swiss-Prot
    B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51523.2 GenPept UniProtKB/Swiss-Prot:P51523

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