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ZNF80 zinc finger protein 80 [ Homo sapiens (human) ]

Gene ID: 7634, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF80provided by HGNC
Official Full Name
zinc finger protein 80provided by HGNC
Primary source
HGNC:HGNC:13155
See related
Ensembl:ENSG00000174255 MIM:194553; AllianceGenome:HGNC:13155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pT17
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 1.1), appendix (RPKM 0.6) and 7 other tissues See more
Orthologs
all
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Genomic context

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Location:
3q13.31
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (114234631..114237578, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116955563..116958509, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113953478..113956425, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dopamine receptor D3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113871254-113871787 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:113873145-113873654 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:113873655-113874164 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:113932583-113933256 Neighboring gene ZNF80-LTR promoter Neighboring gene ATOSB pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:113993502-113994701 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr3:114009187-114010130 and GRCh37_chr3:114010131-114011073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:114017997-114018498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:114018499-114018998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20274 Neighboring gene uncharacterized LOC124909411 Neighboring gene T cell immunoreceptor with Ig and ITIM domains

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family. Di Cristofano A, et al. Nucleic Acids Res, 1995 Aug 11. PMID 7659503, Free PMC Article
  2. Chromosomal localization of four human zinc finger cDNAs. Huebner K, et al. Hum Genet, 1993 Apr. PMID 8478004
  3. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 80
Names
ZNFPT17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007136.4 → NP_009067.2  zinc finger protein 80

    See identical proteins and their annotated locations for NP_009067.2

    Status: VALIDATED

    Source sequence(s)
    AC093010
    Consensus CDS
    CCDS2979.1
    UniProtKB/Swiss-Prot
    P51504, Q6NSW4, Q6NT14
    Related
    ENSP00000417192.3, ENST00000482457.4
    Conserved Domains (3) summary
    COG5048
    Location:51 → 227
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:107 → 127
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:175 → 200
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    114234631..114237578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    116955563..116958509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51504.2 GenPept UniProtKB/Swiss-Prot:P51504

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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