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ZNF79 zinc finger protein 79 [ Homo sapiens (human) ]

Gene ID: 7633, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF79provided by HGNC
Official Full Name
zinc finger protein 79provided by HGNC
Primary source
HGNC:HGNC:13153
See related
Ensembl:ENSG00000196152 MIM:194552; AllianceGenome:HGNC:13153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pT7
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.5), thyroid (RPKM 1.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
9q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127424382..127445372)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139631324..139652321)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130186661..130207651)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GTPase activating Rap/RanGAP domain like 3 Neighboring gene uncharacterized LOC124902275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130146967-130147700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130168662-130169228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180180-130180827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180828-130181474 Neighboring gene solute carrier family 2 member 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130185748-130186690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29040 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:130211857-130212400 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130212943-130213486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130226533-130227033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130226032-130226532 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130251390-130251970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130251971-130252551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130256483-130257002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130262849-130263350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky R, et al. Nucleic Acids Res, 1997 Oct 1. PMID 9380504, Free PMC Article
  2. Chromosomal localization of four human zinc finger cDNAs. Huebner K, et al. Hum Genet, 1993 Apr. PMID 8478004
  3. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Rousseau-Merck MF, et al. Hum Genet, 1993 Dec. PMID 8262519
  4. The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, et al. Mol Cell Biol, 1999 Dec. PMID 10567577, Free PMC Article
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 79
Names
ZNFpT7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286696.2 → NP_001273625.1  zinc finger protein 79 isoform b

    See identical proteins and their annotated locations for NP_001273625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI301044, AK302284, AK316233, DA001397
    Consensus CDS
    CCDS69664.1
    UniProtKB/TrEMBL
    F5H032
    Related
    ENSP00000478201.1, ENST00000612342.4
    Conserved Domains (4) summary
    COG5048
    Location:182 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:435 → 460
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:16 → 74
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  2. NM_001286697.2 → NP_001273626.1  zinc finger protein 79 isoform b

    See identical proteins and their annotated locations for NP_001273626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI301044, AK302284, AK316233, DA001397
    Consensus CDS
    CCDS69664.1
    UniProtKB/TrEMBL
    F5H032
    Related
    ENSP00000438418.1, ENST00000543471.5
    Conserved Domains (4) summary
    COG5048
    Location:182 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:435 → 460
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:16 → 74
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. NM_001286698.2 → NP_001273627.1  zinc finger protein 79 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' terminal exon and lacks two alternate exons in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI301044, AK302284, AK316233, BP248437, DA001397
    Consensus CDS
    CCDS75904.1
    UniProtKB/TrEMBL
    A0A087X2B0
    Related
    ENSP00000484833.1, ENST00000617266.2
    Conserved Domains (3) summary
    COG5048
    Location:72 → 303
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:61 → 81
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:185 → 210
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001322260.2 → NP_001309189.1  zinc finger protein 79 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), along with variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AL445222
    Consensus CDS
    CCDS69664.1
    UniProtKB/TrEMBL
    F5H032
    Conserved Domains (4) summary
    COG5048
    Location:182 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:435 → 460
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:16 → 74
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. NM_007135.3 → NP_009066.2  zinc finger protein 79 isoform a

    See identical proteins and their annotated locations for NP_009066.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI301044, AK054606, BC062309, BP351823
    Consensus CDS
    CCDS6871.1
    UniProtKB/Swiss-Prot
    Q15937, Q5VVW1, Q96NV1
    Related
    ENSP00000362446.4, ENST00000342483.5
    Conserved Domains (5) summary
    cd07765
    Location:40 → 77
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:40 → 98
    KRAB; krueppel associated box
    COG5048
    Location:206 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:195 → 215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319 → 344
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127424382..127445372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717279.4 → XP_006717342.1  zinc finger protein 79 isoform X1

    See identical proteins and their annotated locations for XP_006717342.1

    UniProtKB/TrEMBL
    F5H032
    Conserved Domains (4) summary
    COG5048
    Location:182 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:435 → 460
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:16 → 74
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139631324..139652321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363759.1 → XP_054219734.1  zinc finger protein 79 isoform X1

    UniProtKB/TrEMBL
    B4DY65
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15937.2 GenPept UniProtKB/Swiss-Prot:Q15937

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