Osbp oxysterol binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Osbpprovided by MGI
Official Full Name: oxysterol binding proteinprovided by MGI
Primary source: MGI:MGI:97447
See related: Ensembl:ENSMUSG00000024687 AllianceGenome:MGI:97447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4220; 1110018F06Rik
Summary: Predicted to enable several functions, including phosphatidylinositol-4-phosphate binding activity; sterol binding activity; and sterol transfer activity. Predicted to be involved in several processes, including positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of secretory granule organization; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within lipid transport. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina nuclear layer. Orthologous to human OSBP (oxysterol binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 14.9), heart adult (RPKM 13.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.58 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (11943208..11971478)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (11965844..11994114)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OSBP may be a target and downstream effector of miR-124 for regulating neurite outgrowth and elongation.
Title: MicroRNA124 Regulated Neurite Elongation by Targeting OSBP.
roles of different ORP proteins as regulators of macrophage lipid composition, with implications for inflammatory signaling
Title: Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins.
OSBP opposes the activity of LXR by negatively regulating ABCA1 activity in the cytoplasm by sterol-binding domain-dependent protein destabilization
Title: OSBP negatively regulates ABCA1 protein stability.
Partitioning of Osbp between the endoplasmic reticulum and the Golgi apparatus is regulated by Vapa.
Title: VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH118380 (e-PCR)
- UniSTS:160803

AA818574 (e-PCR)
- UniSTS:249719

AW559088 (e-PCR)
- UniSTS:181205

Osbp (e-PCR), detects polymorphism
- UniSTS:265466

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in sphingomyelin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sterol transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oxysterol-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033174.1 → NP_001028346.1 oxysterol-binding protein 1

See identical proteins and their annotated locations for NP_001028346.1

Status: VALIDATED

Source sequence(s)

AI450082, AK220301, BC107327, CJ163670

Consensus CDS

CCDS37925.1

UniProtKB/Swiss-Prot

E9QPD4, Q3B7Z2, Q3V163, Q52KH7, Q570Y8

Related

ENSMUSP00000025590.10, ENSMUST00000025590.11

Conserved Domains (3) summary

cd13284
Location:89 → 187

PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain

pfam00169
Location:89 → 179

PH; PH domain

pfam01237
Location:416 → 785

Oxysterol_BP; Oxysterol-binding protein