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Grhpr glyoxylate reductase/hydroxypyruvate reductase [ Mus musculus (house mouse) ]

Gene ID: 76238, updated on 21-Apr-2024

Summary

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Official Symbol
Grhprprovided by MGI
Official Full Name
glyoxylate reductase/hydroxypyruvate reductaseprovided by MGI
Primary source
MGI:MGI:1923488
See related
Ensembl:ENSMUSG00000035637 AllianceGenome:MGI:1923488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glxr; 1110059D05Rik; 6430629L09Rik
Summary
This gene encodes a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. The encoded protein catalyzes three enzymatic reactions: the conversion of hydroxypyruvate to D-glycerate as well as the reverse reaction, and the conversion of glyoxylate to glycolate. Homozygous knockout mice exhibit elevated synthesis of oxalate and glycerate. [provided by RefSeq, Aug 2015]
Expression
Broad expression in liver E18 (RPKM 121.1), kidney adult (RPKM 116.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 23.65 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44981394..44990734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44981394..44990734)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30763 Neighboring gene STARR-positive B cell enhancer ABC_E8808 Neighboring gene STARR-positive B cell enhancer ABC_E2110 Neighboring gene predicted gene 12679 Neighboring gene STARR-positive B cell enhancer ABC_E6170 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis. Zong C, et al. Pathol Res Pract, 2016 May. PMID 26997491
  2. Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity. Wood KD, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Sep 1. PMID 31055082, Free PMC Article
  3. Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Knight J, et al. Am J Physiol Renal Physiol, 2012 Mar 15. PMID 22189945, Free PMC Article
  4. Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. Genolet R, et al. J Biol Chem, 2005 Jun 24. PMID 15840574
  5. The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. Buchalski B, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Mar 1. PMID 31821850, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggested that GRHPR might exert its pro-apoptosis function in intestinal epithelial cells. Thus, GRHPR might play an important role in regulating IECs apoptosis, and might be a potential therapeutic target for Crohn's disease.
    Title: Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
  2. data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle
    Title: Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables glycerate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyoxylate reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables hydroxypyruvate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dicarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glyoxylate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
NP_001299809.1
NP_525028.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312880.1 → NP_001299809.1  glyoxylate reductase/hydroxypyruvate reductase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR, resulting in the use of a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK004307, AK018293, AL824706, BB869843, CF738475
    Conserved Domains (2) summary
    COG1052
    Location:1 → 182
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cl21454
    Location:1 → 174
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_080289.2 → NP_525028.1  glyoxylate reductase/hydroxypyruvate reductase isoform 1

    See identical proteins and their annotated locations for NP_525028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK004307, AL824706, BB869843, CF738475
    Consensus CDS
    CCDS18128.1
    UniProtKB/Swiss-Prot
    Q91Z53
    UniProtKB/TrEMBL
    Q3T9Z2
    Related
    ENSMUSP00000047218.7, ENSMUST00000045078.13
    Conserved Domains (2) summary
    COG1052
    Location:1 → 327
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:7 → 319
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    44981394..44990734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z53.1 GenPept UniProtKB/Swiss-Prot:Q91Z53

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